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Administrative data

Workers - Hazard via inhalation route

Systemic effects

Acute/short term exposure
DNEL related information

Local effects

Acute/short term exposure
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Acute/short term exposure
DNEL related information

Workers - Hazard for the eyes

Additional information - workers

2,6-DMA is a carcinogen in rats causing invasive tumours of the nasal cavity. These tumours develop in tissues which show inflammatory processes at the same time and prior to the occurrence of tumours. It remains open whether inflammatory and toxic effects play a rote in tumour development. However, 2,6-DMA is N-oxidised to genotoxic products, binds to DNA at the target tissue, and forms a type of DNA-adduct analogue to that observed with genotoxic carcinogenic polycyclic arylamines.Hence, the mode of action of nasal tumour development in experimental animals remains open. Under these conditions, no health-based DNEL/DMEL can be derived.

General Population - Hazard via inhalation route

Systemic effects

Acute/short term exposure
DNEL related information

Local effects

Acute/short term exposure
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Acute/short term exposure
DNEL related information

General Population - Hazard via oral route

Systemic effects

Acute/short term exposure
DNEL related information

General Population - Hazard for the eyes

Additional information - General Population