Registration Dossier
Registration Dossier
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EC number: 201-758-7 | CAS number: 87-62-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Toxicity and Skin Corrosion Data for Some Organic and Inorganic Compounds and Aqueous Solutions
- Author:
- Vernot EH et al.
- Year:
- 1 977
- Bibliographic source:
- Toxicol. Appl. Pharmacol. 42, 417-423
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Single oral dose toxicity was determined by the method of Smyth et al . (1962).
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,6-xylidine
- EC Number:
- 201-758-7
- EC Name:
- 2,6-xylidine
- Cas Number:
- 87-62-7
- Molecular formula:
- C8H11N
- IUPAC Name:
- 2,6-dimethylaniline
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2,6-dimethylaniline
- no further data
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200-300 g
- Diet Purina Formulab Chow 5008 ad libitum
- Water ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- no
- Details on study design:
- no data
- Statistics:
- LD50 and its 95% confidence limits are estimated by the moving average technique (Thompson, 1947 ; Weil, 1952).
When fractional mortality was not noted, the LD50 value was listed without a confidence interval.
Occasionally enough data were obtained to use the probit method (Finney, 1971) for calculation.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 230 mg/kg bw
- 95% CL:
- >= 890 - <= 1 700
- Mortality:
- no data
- Clinical signs:
- other: no data
- Gross pathology:
- no data
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
