Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: short report

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Principles of method if other than guideline:
Single oral application per gavage, observation time 14 days
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Manganese ferrite black spinel
EC Number:
269-056-3
EC Name:
Manganese ferrite black spinel
Cas Number:
68186-94-7
Molecular formula:
(Fe,Mn)3O4
IUPAC Name:
diiron(3+) dimanganese(3+) manganese(2+) λ²-iron(2+) octaoxidandiide
Test material form:
solid: particulate/powder

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
10000 mg/kg bw
No. of animals per sex per dose:
10
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
discriminating dose
Effect level:
> 10 000 mg/kg bw

Any other information on results incl. tables

no mortality, no symptoms

Applicant's summary and conclusion

Executive summary:

Single oral application per gavage, observation time 14 days

Result: no symptoms, no mortality

Discriminating dose > 10000 mg/kg bw