Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-195-4 | CAS number: 929-06-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990-10-31
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was performed according to OECD 404 guideline and in compliance with the GLP Regulations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-(2-aminoethoxy)ethanol
- EC Number:
- 213-195-4
- EC Name:
- 2-(2-aminoethoxy)ethanol
- Cas Number:
- 929-06-6
- Molecular formula:
- C4H11NO2
- IUPAC Name:
- 2-(2-aminoethoxy)ethan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): 6398-21-1
- Physical state: clear, colorless liquid
- Analytical purity: responsibility of the Sponsor
- Stability under test conditions: no apparent change in the physical state of the test article during administration
- Other: total amount submitted :1408.3g (materials and containers)/pH=10 (litmus paper)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hare-Marland, Hewitt, NJ
- Age at study initiation: adult
- Weight at study initiation: 2.504-2.865 kg
- Housing:Rabbits were housed individually in cages sized in accordance with the "Guide for the Care and Use of Laboratory Animals" of the
Institute of Laboratory Animal Resources, National Research Council.
- Diet (e.g. ad libitum): Purina Rabbit Ration HF, ad libitum
- Water (e.g. ad libitum): fresh tap water, ad libitum.
- Acclimation period: min.5d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C±3°C (63-73°F)
- Humidity (%): 30-70%
- Photoperiod (hrs dark / hrs light):12h light, 12h dark
IN-LIFE DATES: From: To:
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: shaved and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: OECD 404: untreated area of the test animal serves as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5mL/site - Duration of treatment / exposure:
- 4h (upper: intact dorsal trunk)
24h (lower: intact and abraded dorsal trunk) - Observation period:
- 14d
- Number of animals:
- 6 (3M and 3F)
- Details on study design:
- TEST SITE
- Area of exposure: dorsal trunk (clipped free of fur)
- Type of wrap if used: rubber dam and an elastic bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done):
- Time after start of exposure: 4 and 24h
SCORING SYSTEM: observation
Draize Evaluation of Dermal Irritation (Primary Irritation Index) and Modified Primary Irritation Index
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Score:
- 8
- Remarks on result:
- other: 8=severe dermal irritation
- Irritation parameter:
- erythema score
- Basis:
- animal: 6/6
- Time point:
- other: 30min (4h exposure)
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- 14d observation
- Remarks on result:
- other: severe erythema, sloughing, fissuring and necrosis
- Irritation parameter:
- edema score
- Basis:
- animal: 6/6
- Time point:
- other: 30min (4h exposure)
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- 14d observation
- Remarks on result:
- other: severe edema, sloughing, fissuring and necrosis
- Irritation parameter:
- erythema score
- Basis:
- animal: 6/6
- Time point:
- other: 24h (24h exposure)
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- 14d observation
- Remarks on result:
- other: severe erythema, necrosis, sloughing and fissuring
- Irritation parameter:
- edema score
- Basis:
- animal: 6/6
- Time point:
- other: 24h (24h exposure)
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- 14d observation
- Remarks on result:
- other: severe edema, sloughing and fissuring
- Irritant / corrosive response data:
- irreversible severe erythema (including necrosis, sloughing, fissuring) and severe edema is observed 30 min after 4h exposure. The skin damage remained throughout the study (14d)
Applicant's summary and conclusion
- Conclusions:
- The test article was considered to be a severe dermal irritant at both 4 and 24 hour exposures.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

Route: .live1