Registration Dossier

Administrative data

Description of key information

Irritation:
- skin: corrosive
- eye: corrosive

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Skin irritation:

The application of the test substance caused slight erythema after a 1 and 5 min exposure and moderate to severe erythema after a 15 min or 20 h exposure. After 15 min of exposure one animal developed necrosis 72 post exposure. 20 h of exposure led to anaemic necrosis which developed in 1 animal to hart necrosis at the end of the observation period (BASF AG 1969; reliability score 2). In two further skin irritation studies which are available as secondary sources, after a 1-3 min exposure no signs of irritation were observed. Slight to severe erythema were observed after a 60 min and 4 hour exposure period. Moderate oedema was also observed after 4 hours. (Huntsman et al. 1984; reliability score: 2). In a 4 h and 24 h exposure study severe erythema, oedema and necrosis, sloughing, fissuring were observed at the application sites (Huntsman et al. 1992; reliability score: 1).

 

Eye irritation:

In a primary eye irritation study in rabbits, 50 µL of the test substance caused moderate to severe irreversible corneal opacity, irritis, moderate erythema and slight to moderate chemosis. At the end of the observation period after 8 days staphyloma and severe corneal opacity were noted (BASF AG 1969; reliability score 2). A further publication confirmed these severe corrosive effects (Smyth et al. 1951; reliability score: 2).


Effects on skin irritation/corrosion: corrosive

Effects on eye irritation: corrosive

Effect level: empty Endpoint conclusion: Adverse effect observed

Justification for classification or non-classification

EU classification according to Annex I of Directive 67/548/EEC: C; R34