Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

2-(2-aminoethoxy)ethanol was evaluated at 10% concentration for dermal sensitization in 20 guinea pigs (10 f, 10 m) for a 3 x 6 hour induction period. Animals were challenged after 14 days and one positive response was observed after 24 and 48 hours relative to 100% response (5/5) in the positive control group. In a rechallenge after 7 days 2/20 positive responses were observed after 24 and 48 hours (Huntsman 1991; reliability score: 2).

A minimum figure of 15% under any study would be necessary for classification as a sensitizer. Practical experience over 20 years of manufacturing this product adds weight to this conclusion.


Migrated from Short description of key information:
Skin sensitisation: not sensitizing.
Respiratory sensitisation: no data available.

Respiratory sensitisation

Endpoint conclusion
Additional information:

Altough 10 % of the animals showed a positive result, a minimum figure of 15% under any study would be necessary for classification as a sensitizer under EU standards.

No EU classification according to Annex I of Directive 67/548/EEC.


Migrated from Short description of key information:
No data available for the determination of the respiratory sensitisation potential.

Justification for classification or non-classification

No EU and / or GHS classification warranted.