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Administrative data

Description of key information

Acute Toxicity:
- oral: LD50: 3400kg/kg bw (rat);
- inhalation: no mortality after 8 h saturated vapor.
- dermal: > 3000 mg/kg bw (OECD 402);

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
LD50
Value:
3 400 mg/kg bw

Additional information

Oral:

In a study which was in large parts equivalent to methods described in OECD guideline 401, the LD50 for oral acute toxicity in rats was calculated as ca. 3400 mg/kg body weight (BASF AG, 1969; reliability score: 2). Doses of 212, 1696, 2120, 2650, 3392, 4240, 5300, and 6784 mg/kg bw of an aqueous solution were applied by gavage followed by a post dose observation period of 7 days. Main clinical signs observed were staggering, apathy, irregular respiration, shallow flanks, abdomial position, closed eyes, ruffled fur. At necropsy, gastrorrhagia, sagged gastrointestinal tract and serous smeared snouts were observed. In two supporting studies with only limited data provided, the test substance caused likewise low toxicity after a single ingestion (LD50 = 2558 mg/kg bw; Huntsman 1991; relibility score 2, LD50=5660 mg/kg bw; Smyth et al. 1951; reliability score: 2).

Inhalation:

The inhalation of a saturated vapor-air mixture for 8 hours caused no mortality in two inhalation risk tests. No clinical signs or indications at necropsy were observed (BASF AG, 1969; reliability score 2; Smyth et al. 1951; reliability score: 2).

Dermal:

In the Key study an LD50 > 3000 mg/kg bw was reported

(Huntsman 1991; reliability score 1).

In the available limit-test as secondary source the acute dermal toxicity of 2-(2-aminoethoxy)ethanol was evaluated in rats according to OECD guideline 402 and in compliance with GLP. No mortalities were observed at the highest test dose level of 3000 mg/kg bw. Observations noted on live animals included decreased activity, poor grooming, diarrhoea, abnormal gait and stance and dyspnoea. A clear mucous anal discharge and a yellow discolouration of fur, with necrosis and skin sloughing surrounding the application site were observed. Terminal necropsy of animals revealed severe irritation and/or yellow discolouration of the underlying muscle tissue at the application site and also necrotic or discoloured fascia. Mottled lungs and pale kidneys were observed. A dermal LD50 value of 1190 µl/kg bw, equivalent to 1260 mg/kg bw was published in a study for rabbits, with no further details provided (Smyth et al.1966; reliability score: 2).

Justification for classification or non-classification

No EU and / or GHS classification warranted.