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EC number: 213-195-4 | CAS number: 929-06-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented report whcih meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2-(2-aminoethoxy)ethanol
- EC Number:
- 213-195-4
- EC Name:
- 2-(2-aminoethoxy)ethanol
- Cas Number:
- 929-06-6
- Molecular formula:
- C4H11NO2
- IUPAC Name:
- 2-(2-aminoethoxy)ethan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): 2,2-Aminoethoxyethanol
- Analytical purity: 99.6 %
- Other: room temperature
Constituent 1
Method
- Target gene:
- Histidin operon
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9-mix from Aroclor 1254 treated male Sprague-Dawley rats.
- Test concentrations with justification for top dose:
- All tester strains: 0, 20, 100, 500, 2500 and 5000 ug/plate (standard plate test and preincubation test);
TA 98: 12.5, 25, 50 and 100 ug/plate (preincubation test) - Vehicle / solvent:
- - Vehicle(s)/solvent(s) used: water
Controls
- Untreated negative controls:
- yes
- Remarks:
- water control
- Negative solvent / vehicle controls:
- yes
- Remarks:
- sterility control
- True negative controls:
- no
- Positive controls:
- yes
- Positive control substance:
- other: with S-9 mix: all strains 2-aminoanthracene; without S-9 mix: strains TA100, TA1535: N-methyl-N'-nitro-N-nitrosoguanidine; TA98: 4-nitro-o-phenylendiamine; TA1537: 9-aminoacridine
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: preincubation
DURATION
- Preincubation period: 20 min
- Exposure duration: 48 h
NUMBER OF REPLICATIONS: 3
METHOD OF APPLICATION: standard plate test
DURATION
- Exposure duration: 48 h
NUMBER OF REPLICATIONS: 3 - Evaluation criteria:
- The test chemical is considered positive in this assay if the following criteria are met: A dose-related and reproducible increase in the number of revertant colonies, i.e. about doubling of the spontaneous mutation rate in at least one tester strain either without S-9 mix or after adding a metabolizing system.
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- in the preincubation test without S-9 mix depending on the strain at doses > 2500 µg/plate.
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- TEST-SPECIFIC CONFOUNDING FACTORS
- Water solubility: Complete solubility of test substance in aqua dest. - Remarks on result:
- other: other: Salmonella typhimurium TA1535, TA100, TA1537, TA98
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Standart plate test:
Dose (µg/plate) | TA1535 | TA100 | TA1537 | TA98 | |||||||||||||||||||||||||||||
-S9 | +S9 | -S9 | +S9 | -S9 | +S9 | -S9 | +S9 | ||||||||||||||||||||||||||
0 | 19±4 | 16±2 | 95±10 | 104±11 | 9±1 | 12±3 | 24±5 | 30±2 |
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20 | 15±6 | 11±6 | 103±13 | 107±7 | 10±3 | 14±4 | 23±4 | 33±2 |
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100 | 18±6 | 17±2 | 103±12 | 105±3 | 7±2 | 13±1 | 22±2 | 33±3 |
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500 | 14±5 | 17±5 | 93±21 | 99±9 | 13±2 | 18±2 | 17±2 | 36±6 |
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2500 | 16±6 | 20±1 | 102±4 | 92±10 | 9±3 | 14±2 | 20±4 | 37±4 |
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5000 | 14±4 | 21±2 | 90±11 | 107±7 | 14±6 | 18±3 | 21±1 | 30±2 |
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2AA | - | 215±10 | - | 1029±22 | - | 180±17 | - | 1003±61 |
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MNNG | 1332±112 | - | 1373±90 | - | - | - | - | - |
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AAC | - | - | - | - | 354±56 | - | - | - |
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NOPD | - | - | - | - | - | - | 861±14 | - |
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Mean ± SD
Preincubation-test:
Dose (µg/plate) | TA1535 | TA100 | TA1537 | TA98 | |||||||||||||||||||||||||||||
-S9 | +S9 | -S9 | +S9 | -S9 | +S9 | -S9 | +S9 | ||||||||||||||||||||||||||
0 | 12±2 | 12±1 | 82±4 | 100±9 | 7±2 | 11±2 | 20±2 | 37±4 |
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20 | 12±4 | 14±2 | 76±3 | 93±16 | 8±3 | 13±3 | 18±6 | 60±2 |
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100 | 11±4 | 13±1 | 79±3 | 107±9 | 6±4 | 15±1 | 24±5 | 46±5 |
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500 | 13±6 | 11±4 | 87±2 | 88±10 | 5±2 | 13±2 | 27±1 | 53±8 |
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2500 | 16±3 | 14±2 | 61±2 | 86±5 | 7±3 | 10±3 | 21±9 | 49±8 |
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5000 | 10±8 | 16±3 | 42±12 | 81±6 | x | 15±5 | 14±2 | 34±3 |
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2AA | - | 271±15 | - | 1415±74 | - | 113±26 | - | 1330±95 |
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MNNG | 1310±216 | - | 1335±88 | - | - | - | - | - |
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AAC | - | - | - | - | 426±96 | - | - | - |
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NOPD | - | - | - | - | - | - | 804±62 | - |
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Mean ± SD
Preincubation-test:
Dose (µg/plate) | TA98 | ||||||||||||||||||||||||||||||||
-S9 | +S9 | ||||||||||||||||||||||||||||||||
0 | 26±4 | 34±2 |
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12.5 | 22±2 | 35±4 |
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25 | 20±6 | 36±3 |
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50 | 28±2 | 33±2 |
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100 | 26±3 | 33±2 |
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2AA | - | 753±8 |
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NOPD | 844±33 | - |
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Mean ± SD
X: reduced background growth
2-AA: 2-aminoanthracene;
MNNG; N-methyl-N-nitro-N-nitrosoguanidine
NOPD: 4-nitro-o-phenylendiamine
AAC: 9-aminoacridine chloride monohydrate
Under the conditions tested 2-(2-aminoethoxy)ethanol in non mutagenic in the bacterial AMES-test.
The positive controls gave the expected values.
Applicant's summary and conclusion
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