Registration Dossier
Registration Dossier
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EC number: 203-058-7 | CAS number: 102-82-9
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1984
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
- Principles of method if other than guideline:
- subacute toxicity test
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Tributylamine
- EC Number:
- 203-058-7
- EC Name:
- Tributylamine
- Cas Number:
- 102-82-9
- Molecular formula:
- C12H27N
- IUPAC Name:
- tributylamine
- Details on test material:
- - Name of test material (as cited in study report): Tributylamine, not further specified
Constituent 1
Test animals
- Species:
- other: rat, mouse
- Strain:
- other: white
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 3 days
- Frequency of treatment:
- 1x/d
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1/3 of LD50
- No. of animals per sex per dose:
- no data
- Control animals:
- other: no data specified
Results and discussion
Effect levels
- Dose descriptor:
- LOAEL
- Effect level:
- ca. 36 mg/kg bw/day (nominal)
- Sex:
- not specified
- Basis for effect level:
- other: effects on liver enzymes metabolising xenobiotics, lipid peroxidation, intercellular shift from SH- to SS-groups
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- No conclusions can be drawn based on the available data.
- Executive summary:
Intraperitoneal injections of 1/3 the LD50 (approx. 36 mg/kg bw) into white rats and mice of unspecified strain produced effects on xenobiotic-metabolising liver enzymes 24 h after the last dosing: there was a prolongation of the hexobarbital sleeping time, an increased activity of the monoamine oxidase and a decrease in the activity of the activity of the succinate dehydrogenase. The amount of urinary antipyrine metabolites were reduced. There was also an increase in lipid peroxidation and a decrease in the content of intercellular free SH groups as well as an increase in SS-groups (Sidorin et al., 1984).
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