Registration Dossier
Registration Dossier
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EC number: 203-058-7 | CAS number: 102-82-9
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented publication, but of limited relevance for information requirements
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
- Type of study / information:
- olfactory sensation/odour threshold test
- Principles of method if other than guideline:
- no guideline required
- GLP compliance:
- no
Test material
- Reference substance name:
- Tributylamine
- EC Number:
- 203-058-7
- EC Name:
- Tributylamine
- Cas Number:
- 102-82-9
- Molecular formula:
- C12H27N
- IUPAC Name:
- tributylamine
- Details on test material:
- - Name of test material (as cited in study report): tri-n-butylamine
- Analytical purity: > 99.5%
Constituent 1
Method
- Ethical approval:
- not specified
- Details on study design:
- 8 female and 8 male volunteers (randomly selected from 46 volunteers) were exposed to the test substance in 6 varying concentrations (not stated in detail) and to blank samples to determine an odour threshold. Therefore, a single entry of 6 sec was performed and not exhaled until they had withdrawn
- Exposure assessment:
- measured
Results and discussion
- Results:
- An odour threshold (100% recognition) of 0.07 +/- 0.03 ppm (approx. 0.54 mg/m3) was identified in this study (lowest value: 0.01 ppm).
Applicant's summary and conclusion
- Conclusions:
- No conclusions can be drawn with respect to information requirements.
- Executive summary:
8 female and 8 male volunteers were exposed to the test substance (> 99.5% pure) in varying concentrations. An odour threshold of 0.07 +/- 0.03 ppm (approx. 0.54 mg/m3) was identified in this study (lowest value: 0.01 ppm) (Laing et al., 1978).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
