Registration Dossier

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1973
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Unsuitable test system

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1973
Report Date:
1973

Materials and methods

Type of study / information:
Nitrosation of amines
Principles of method if other than guideline:
no guideline required
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): tri-n-butylamine, not further specified

Results and discussion

Any other information on results incl. tables

Di-n-butylnitrosoamine was formed from 0.5 M,0.1 M, and 0.02 M tri-n-butylamine in the presence of excess nitrite (4-molar excess) at a yield of 14 %, 1 % and 0.4 % after 4h  at pH 3.7 - 4.0 and 37 °C, respectively.

Applicant's summary and conclusion

Executive summary:

Di-n-butylnitrosoamine was formed from 0.5 M,0.1 M, and 0.02 M tri-n-butylamine in the presence of excess nitrite (4-molar excess) at a yield of 14 %, 1 % and 0.4 % after 4h  at pH 3.7 - 4.0 and 37 °C, respectively (Lijinski et al., 1973).