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EC number: 201-058-1 | CAS number: 77-78-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reliable well documented study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Transplacental genetic and cytogenetic effects of alkylating agents in the mouse I: Induction of somatic coat color mutations
- Author:
- Braun R et al.
- Year:
- 1 984
- Bibliographic source:
- Terat Carcinog Mutagen 4:449-457
- Reference Type:
- secondary source
- Title:
- EU Risk Assessment Report Dimethyl Sulphate
- Author:
- European Chemicals Bureu
- Year:
- 2 002
- Bibliographic source:
- EU RAR, Volume 12, Luxembourg 2002
Materials and methods
- Type of study / information:
- Mouse spot test
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD 484
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Dimethyl sulphate
- EC Number:
- 201-058-1
- EC Name:
- Dimethyl sulphate
- Cas Number:
- 77-78-1
- Molecular formula:
- C2H6O4S
- IUPAC Name:
- dimethyl sulfate
Constituent 1
Results and discussion
Any other information on results incl. tables
DMS did not induce RS frequency in both crosses.
Table 1: Frequency of RS, WMVS and MDS in offsring derived from the cross NMRI x DBA
Compound |
Dose (mg/kg) |
Treatment day |
No. of females treated |
No. of litters |
No. of offspringa |
Average litter sizea |
Offspring with |
P |
||
RS (%) |
WMVS (%) |
MDS (%) |
||||||||
DMS |
50 |
10.25 |
60 |
42 |
387 (201) |
9.2 (4.7) |
0 (0) |
0 (0) |
0 (0) |
> 0.05 |
a: These columns refer to the total number of offspring while the number of non-agouti offspring is given in brackets.
Table 2: Frequency of RS, WMVS and MDS in offspring derived from the cross C57 x T-stock at day 10.25 of embryonal development
Compound |
Dose (mg/kg) |
No. of females treated |
No. of litters |
No. of offspring |
Average litter size |
Offspring with |
P |
||
RS (%) |
WMVS (%) |
MDS (%) |
|||||||
DMS |
25 |
87 |
28 |
181 |
6.5 |
2 (1.10) |
2 (1.10) |
0 (0) |
> 0.05 |
DMS did not induce mutations up to the highest concentration.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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