Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-058-1 | CAS number: 77-78-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: case report
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented german case report, no data on purity and concentration of test item
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Zur Toxikologie des Dimethylsulfats
- Author:
- Rossmann H
- Year:
- 1 952
- Bibliographic source:
- Zbl. Arbeitsmed. Arbeitsschutz 2, 72-75
- Reference Type:
- publication
- Title:
- Recommendation from the Scientific Commitee on Occupational Exposure Limits for dimethyl sulphate
- Author:
- SCOEL
- Year:
- 2 004
- Bibliographic source:
- SCOEL/SUM/111 November 2004
Materials and methods
- Study type:
- other: accidental exposure
- Endpoint addressed:
- acute toxicity: inhalation
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
Test material
- Reference substance name:
- Dimethyl sulphate
- EC Number:
- 201-058-1
- EC Name:
- Dimethyl sulphate
- Cas Number:
- 77-78-1
- Molecular formula:
- C2H6O4S
- IUPAC Name:
- dimethyl sulfate
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- - Number of subjects exposed: 2
- Sex: male
- Age: 40 years old - Ethical approval:
- not applicable
- Route of exposure:
- inhalation
- Reason of exposure:
- accidental
- Exposure assessment:
- estimated
- Details on exposure:
- Accidental exposure to DMS of two male employees during cleaning and repairing of DMS filling station without wearing respiratory mask.
Temperature: 4 °C
Exposure duration: 3 hours - Examinations:
- Necropsy after fatal death of one employee
- Medical treatment:
- Yes. Strophanthin was administered to support the employee's heart.
Results and discussion
- Clinical signs:
- First employee:
Irritation of mucous membrane of the respiratory tract development of lung oedema.
Death after 3 days
Second employee:
cough, irritation of mucous membrane of the respiratory tract, conjunctivitis and ceratitis.
Employee survived. - Results of examinations:
- First employee:
Gross pathology: oedema in brain, corrosion of pharynx, larynx and trachea
Histopathology: verified oedema in brain and lung - Effectivity of medical treatment:
- not effective: one patient died 3 days after accidental exposure
- Outcome of incidence:
- no data
Applicant's summary and conclusion
- Conclusions:
- DMS is acute toxic.
- Executive summary:
One of two men died after exposure to DMS-vapour for three hours at 4°C without protective clothing (Rossmann 1952). In the person that died, symptoms of intoxication appeared after several hours and consisted of irritation of the upper-respiratory tract and fever. In the hospital he developed irritation of the conjunctivae and glottis oedema. He finally died after 3 days. Autopsy revealed oedema of the lung and brain. Histopathological examination confirmed the pulmonary oedema and showed corrosion of the respiratory tract. The other person reported nasal secretion, dyspnoea, and conjunctivitis of both eyes. The second day of hospitalisation, he also developed fever, after which his general condition improved and with only minor lung problems he was released from hospital on day eight.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
