Registration Dossier
Registration Dossier
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EC number: 201-058-1 | CAS number: 77-78-1
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original reference in foreign language and not yet available
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Pathogenesis of acute dimethyl sulfate poisoning (an experimental study)
- Author:
- Batsura YD, Kasparov AA, Krugilov GG and Molodkina NN
- Year:
- 1 980
- Bibliographic source:
- Gig Tr Prof Zabol; 11: 55-57. Cited in: EU RAR (2002)
- Reference Type:
- secondary source
- Title:
- EU Risk Assessment Report Dimethyl Sulphate
- Author:
- European Chemicals Bureau
- Year:
- 2 002
- Bibliographic source:
- EU RAR, Volume 12. Luxembourg 2002
Materials and methods
- Principles of method if other than guideline:
- Determination of LC50 level in rats after a 4 hr-inhalative exposure to the test substance
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- - Name of test material (as cited in study report): dimethyl sulphate
No further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No additional details
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: air
- Details on inhalation exposure:
- No additional details
- Duration of exposure:
- 4 h
- Concentrations:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
- Details on study design:
- No additional details
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 45 mg/m³ air
- Exp. duration:
- 4 h
- Mortality:
- no data, it is reported that groups of animals were sacrificed immediately following exposure and at intervals thereafter.
- Clinical signs:
- other: The exposed rats were dyspnoeic and some had nasal discharge
- Body weight:
- no data
- Gross pathology:
- cyanosis of the mucosae, hyperemia of the lung, and hemorrhage in the internal organs.
- Other findings:
- Histological and electron microscopic examination of lung tissue revealed hemorrhage and coagulated proteins in the alveoli. After a latent period of 5-6 hr, accumulation of edematous fluid in the air spaces developed progressively over 24-48 hr
Any other information on results incl. tables
-
Applicant's summary and conclusion
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