Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1995
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only extended abstract available

Data source

Reference
Reference Type:
publication
Title:
The role of aldehyde oxidase in the in vivo metabolism of benzothiazole
Author:
Fowler et al.
Year:
1995
Bibliographic source:
Biochem Soc Trans 23, 604S

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Single i.p. administration to guinea pigs, identification of urinary and faecal metabolites
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Benzothiazole
EC Number:
202-396-2
EC Name:
Benzothiazole
Cas Number:
95-16-9
Molecular formula:
C7H5NS
IUPAC Name:
benzothiazole
Details on test material:
- Name of test material (as cited in study report): [³H]-benzothiazole
- Analytical purity: no data

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: Methocel KI5M Premium
Duration and frequency of treatment / exposure:
Single dose
Doses / concentrations
Remarks:
Doses / Concentrations:
44 mg/kg bw
No. of animals per sex per dose / concentration:
no data
Control animals:
not specified
Details on dosing and sampling:
METABOLITE CHARACTERISATION STUDIES
- Tissues and body fluids sampled: urine and faeces were collected on a 24h basis and analysed immediately

Results and discussion

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
Metabolism of 6-[³H]-benzothiazole:
1) 3.5 % 2-methylmercaptoaniline
2) 55 % 2-methylsulphinylaniline
3) 15.5 % 2-methylsulphonylaniline

Applicant's summary and conclusion