Registration Dossier

Toxicological information

Basic toxicokinetics

Currently viewing:

Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
other information
Study period:
1995
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only extended abstract available

Data source

Reference
Reference Type:
publication
Title:
The role of aldehyde oxidase in the in vivo metabolism of benzothiazole
Author:
Fowler et al.
Year:
1995
Bibliographic source:
Biochem Soc Trans 23, 604S

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Single i.p. administration to guinea pigs, identification of urinary and faecal metabolites
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): [³H]-benzothiazole
- Analytical purity: no data

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: Methocel KI5M Premium
Duration and frequency of treatment / exposure:
Single dose
Doses / concentrations
Remarks:
Doses / Concentrations:
44 mg/kg bw
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on dosing and sampling:
METABOLITE CHARACTERISATION STUDIES
- Tissues and body fluids sampled: urine and faeces were collected on a 24h basis and analysed immediately

Results and discussion

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
Metabolism of 6-[³H]-benzothiazole:
1) 3.5 % 2-methylmercaptoaniline
2) 55 % 2-methylsulphinylaniline
3) 15.5 % 2-methylsulphonylaniline

Applicant's summary and conclusion