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EC number: 202-396-2 | CAS number: 95-16-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Benzothiazole was found to be toxic if swallowed, harmful in contact with skin and harmful by inhalation.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 177 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 5 000 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 933 mg/kg bw
Additional information
The acute oral toxicity of benzothiazole was investigated in male and female SPF rats. 6 male and 5 female groups of 10 animals were dosed with 0.1, 0.18, 0.2, 0.23, 0.25, 0.3 mL/kg bw and 0.1, 0.13, 0.15, 0.16, 0.18 mL/kg bw benzothiazole per gavage and observed for 14 days following exposure for mortality and clinical signs. Mortalities occurred at dose levels equal to and exceeding 0.18 mL/kg bw between 8 and 24 hours after administration in male rats and in female rats at dose levels equal to and exceeding 0.13 mL/kg bw between 8 and 24 hours.
Clinical signs like paralysis of the rear extremities, bloody tears, narcosis, prone-/ side position, decreased weight and reduced general condition were observed. The calculated LD50 for male rats was 0.206 mL/kg bw (=258 mg/kg bw) and 0.142 mL/kg bw (=177 mg/kg bw) for female rats
(Loeser, Bayer AG, 1982).
The acute inhalative toxicity of benzothiazole was investigated in study according to OECD guideline 403. Rats were exposed nose/head-only to an atmosphere containing analytical concentrations of 0.377 mg/L (vapour); 2.36 mg/L (aerosol) and 6.154 mg/L (aerosol) benzothiazole for 4 hours. Clinical signs of toxicity were related to dose. Control groups and the 376.5 mg/m³ air groups were without symptoms. Tumbling walk, decreased and increased motility, side-and prone position, decreased and increased respiration, breathing noises, paleness and restricted palpebral fissure were observed at a concentration of 2360.7 mg/m³ air benzothiazole. The clinical signs at 6153.9 mg/m³ air benzothiazole were decreased and increased motility, restricted palpebral fissure, side position, narcotized, complicated respiration, breathing noises, cyanosis, paleness, red noses and lacrimation. Mortalities occurred at 6153.9 mg/m³ air 4 hours after administration.The calculated LC50 was 5000 mg/m³ air (Pauluhn, Bayer AG, 1981).
The acute dermal toxicity of benzothiazole was investigated in 5 male and 5 female rats in a GLP study performed according to guideline study 402.
The animals were dosed with 500, 1000 and 2000 mg/kg body weight benzothiazole. Sedation was observed at dose levels equal to and exceeding 1000 mg/kg body weight. Also chromodakryorrhoe was observed at 1000 mg/kg bw in 3 male rats. Mortalities occurred at dose levels equal to and exceeding 1000 mg/kg bw 1 to 3 days after administration. The calculated LD50 in male rats was 1231 mg/kg body weight and in female rats 933 mg/kg bw (Bomhard, Bayer AG, 1995).
Justification for classification or non-classification
LD50 (oral) = 177 mg/kg bw
Classification:
DSD: T, R25 Harmful if swallowed
GHS: Acute Oral Category 3, H301
LD50 (dermal) = 933 mg/kg bw
Classification:
DSD: Xn, R21 Harmful in contact with skin
GHS: Acute Dermal Category 3, H311
LC50 (inhalation) = 5000 mg/m³
Classification:
DSD: Xn, R20 Harmful by inhalation
GHS: Acute Inhalation Category 4, H332
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