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EC number: 202-396-2 | CAS number: 95-16-9
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- Endpoint summary
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
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- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
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Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- Method according to directive 84/449EEC, B.3.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Benzothiazole
- EC Number:
- 202-396-2
- EC Name:
- Benzothiazole
- Cas Number:
- 95-16-9
- Molecular formula:
- C7H5NS
- IUPAC Name:
- benzothiazole
- Details on test material:
- - Name of test material (as cited in study report): Benzothiazol
- Analytical purity: 97.4 %
- Lot/batch No.: 105488/1990
- Product No.: 680 982 00
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen, Germany
- Age at study initiation: male rats: 10 weeks; female rats: 15 weeks
- Weight at study initiation: males rats: 239 g; female rats: 215 g
- Fasting period before study: no data
- Housing: Macrolon Type II
- Diet (e.g. ad libitum): "fixed-formula" diet, Altromin 1324 pellets, Altromin GmbH & Co. KG, Lage, Germany
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2 °C
- Humidity (%): 50 ± 10 %
- Air changes (per hr): 10 per hour
- Photoperiod (hrs dark / hrs light): Artificial light, sequence being 12 hours light, 12 hours dark
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- polyethylene glycol
- Details on dermal exposure:
- TEST SITE
- Area of exposure: shaved back
- Type of wrap if used: covered by alu and plaster (Fermoflex Klebeband, Beyersdorf AG, Germany)
REMOVAL OF TEST SUBSTANCE
- Washing (if done): rinsed with warm water
- Time after start of exposure: 24 hours - Duration of exposure:
- 24 hours
- Doses:
- 500, 1000 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observation: twice a day; Weighing: 1 week after administration and at day 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- According to Spearmann - Kärber (Angewandte Statistik, 6. Aufl. (1984) 178)
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 231 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 933 mg/kg bw
- Mortality:
- Male rats:
500 mg/kg: 0 of 5
1000 mg/kg: 1 of 5 3 days after application
2000 mg/kg: 5 of 5 1-2 days after application
Female rats:
500 mg/kg: 0 of 5
1000 mg/kg: 3 of 5 1-2 days after application
2000 mg/kg: 5 of 5 1 day after application - Clinical signs:
- other: At 1000 and 2000 mg/kg bw sedation At 1000 mg/kg bw in 3 male rats chromodakryorrhoe
- Gross pathology:
- In places black coloured gastric mucosa and at 2000 mg/kg bw fully filled bladder in died rats.
All at the end of the test killed animals were anatomically inconspicuous.
Any other information on results incl. tables
Acute dermal toxicity of benzothiazole in rats
Dose (mg/kg bw) |
Dead rats / rats used |
Time of death |
Mortality (%) |
Males |
|||
500 1000 2000 |
0 / 5 1 / 5 5 / 5 |
- 3d 1d – 2d |
0 20 100 |
Females |
|||
500 1000 2000 |
0 / 5 3 / 5 5 / 5 |
- 1d – 2d 1d |
0 60 100 |
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Classification:
DSD: Xn, R21 Harmful in contact with skin
GHS: Acute Dermal Category 3, H311 - Executive summary:
Bomhard, Bayer AG, 1995
The GLP study was performed according to guideline study 402. The acute dermal toxicity of benzothiazole was investigated in 5 male and 5 female rats. The animals were dosed with 500, 1000 and 2000 mg/kg body weight benzothiazole. Sedation was observed at dose levels equal to and exceeding 1000 mg/kg body weight. Also chromodakryorrhoe was observed at 1000 mg/kg bw in 3 female rats. Mortalities occurred at dose levels equal to and exceeding 1000 mg/kg bw 1 to 3 days after administration. The calculated LD50 in male rats was 1231 mg/kg body weight and in female rats 933 mg/kg bw.
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