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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Benzothiazole is considered not irritating to the skin and mildly irritating to the eyes.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

The skin irritation potential of benzothiazole was investigated in 3 female New Zealand White rabbits comparable to OECD guideline 404 with acceptable restrictions. A 2.5 x 2.5 cm area of intact shaved animal skin was used to apply the test substance. Gauze pads were loaded with 0.5 mL benzothiazole and the test areas were covered semiocclusive with elastic tape. The exposure duration was 4 hours. The skin was rinsed 4 hours after application of the test substance. The skin irritation reactions were examined and scored using the Draize method 24, 48 and 72 hours after application. The mean erythema score at 24 hours was 0.3. At the 48 and 72 hour reading points the erythema score was 0.0. The mean oedema score at 24, 48 and 72 hour were 0.0 (Suberg, 1983).

The criteria for classification are not fulfilled.

The eye irritation potential of benzothiazole was investigated in 3 male New Zealand White rabbits comparable to OECD guideline 405 with acceptable restrictions. 0.1 mL undissolved test substance was applied into the conjunctival sac of one eye of each animal. The other untreated eye served as control. The eyes were rinsed 24 hours after application of the test substance. The eye irritation reactions were examined and scored using the Draize method 1, 24, 48 and 72 hours after application.

Benzothiazole induced conjunctival redness. The mean scores for the three animals were 1.7, 2.7 and 1.3. For the conjunctiva chemosis the mean scores of 1.3, 1.3 and 1.0 were calculated. Two of three animals showed a cornea opacity mean score of 1.0, for the third animal a mean value of 0.3 was calculated. The mean scores over all three time points for iritis were 0.0 in all animals. All irritation symptoms were reversible 8 days after exposure (Suberg, 1983).

The mean scores for cornea opacity of 1.0 in 2 of 3 animals leads to the UN-GHS classification: Category 2B, Mildly irritating to eyes and to the EU-GHS classification: Category 2, Irritating to eyes. The criteria for DSD classification are not fulfilled.


Effects on eye irritation: slightly irritating

Justification for classification or non-classification

Classification for skin irritation:

DSD: no classification required.

EU-GHS: no classification required

Classification for eye irritation:

DSD: no classification required

UN-GHS: Category 2B, Mildly irritating to eyes, H320: Causes eye irritation

EU-GHS: Category 2, Irritating to eyes, H319: Causes serious eye irritation