Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

Based on a Stimulation Index of 5.5 at the high concentration of Crude 1,3-dichloropropene of 50% v/v, Crude 1,3-dichloropropene is considered to be a skin sensitizer in the LLNA. However, the limitations of the LLNA only allow prediction of the induction phase.


Migrated from Short description of key information:
Crude 1,3-dichloropropene was evaluadted for the potential to induce skin sensitization in an O.E.C.D. Testing Guideline 429 mouse local lymph node assay (LLNA) with GLP compliance.

Respiratory sensitisation

Endpoint conclusion
Additional information:
Migrated from Short description of key information:
No data. Not a required endpoint for a Transported Intermediate dossier (E.C.H.A. Guidance for Intermediates. February 2008).

Justification for classification or non-classification

Based on the positive findings from a mouse local lymph node assay, Crude 1,3 -dichloropropene requires Classification and Labeling as a skin sensitizer.