Registration Dossier

Administrative data

Key value for chemical safety assessment

Additional information

Crude 1,3 -dichloropropene was assessed for mutagenic potential with an O.E.C.D. 471 Testing Guideline study conducted by the preincubation method and GLP compliance. Treatment of tester strains TA 1535, TA 100 and WP2 uvrA with Crude 1,3-dichloropropene with and without rat liver derived S9 metabolic activation perperation resulted in positive mutational responses. Tester strain TA 1535 was the most sensitive indicator of the mutagenic effect of Crude 1,3-dichloropropene. An increase in the mutant frequency that reached 31.4 -fold the control background value was observed for strain TA 1535 with S9 metabolic activation preperation. The data suggest that Crude 1,3-dichloropropene is acting by the induction of point mutations in these bacterial tester strains.


Short description of key information:
Crude 1,3-dichloropropene was assessed for mutagenic potential in an O.E.C.D. Testing Guideline 471 conducted by the preincubation method with GLP compliance.

Endpoint Conclusion: Adverse effect observed (positive)

Justification for classification or non-classification

Insufficient information for Classification and Labeling. There is no in vivo genotoxicity test data for Crude 1,3 -dichloropropene.