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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Title:
Final report on the safety assessment of benzophenones-1, -3, -4, -5, -9, and -11
Author:
Anonymous
Year:
1983
Bibliographic source:
Journal of the American College of Toxicology, Volume 2, Number 5 (1983), page 35-77

Materials and methods

Test guideline
Guideline:
other: FHSLA procedure
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2,4-dihydroxybenzophenone
EC Number:
205-029-4
EC Name:
2,4-dihydroxybenzophenone
Cas Number:
131-56-6
Molecular formula:
C13H10O3
IUPAC Name:
4-benzoylbenzene-1,3-diol

Test animals

Species:
rabbit
Strain:
other: albino

Test system

Type of coverage:
occlusive
Preparation of test site:
abraded
Vehicle:
other: see below
Amount / concentration applied:
0.5 ml test solution on the patch.
Concentrations of the test substance in the test solution were 4, 8 and 16% in petrolatum, respectively dimethyl phthalate
Duration of treatment / exposure:
24 h
Observation period:
24h and 48h (immediately after patch removal and 24 hours after patch removal)
Number of animals:
6
Details on study design:
Scoring according to Draize

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: 24h
Score:
0
Max. score:
8
Reversibility:
other: not applicable (no effects seen)
Remarks on result:
other: application of upto a concentration of 16% of the test substance in petrolatum
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: 24 h
Score:
0.25
Max. score:
8
Reversibility:
fully reversible within: another 24 h
Remarks on result:
other: application of upto a concentration of 16% of the test substance in dimethyl phthalate. Effect was only seen at 16%, not at 4% or 8%

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU