Registration Dossier
Registration Dossier
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EC number: 205-029-4 | CAS number: 131-56-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Title:
- Final report on the safety assessment of benzophenones-1, -3, -4, -5, -9, and -11
- Author:
- Anonymous
- Year:
- 1 983
- Bibliographic source:
- Journal of the American College of Toxicology, Volume 2, Number 5 (1983), page 35-77
Materials and methods
Test guideline
- Guideline:
- other: FHSLA procedure
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,4-dihydroxybenzophenone
- EC Number:
- 205-029-4
- EC Name:
- 2,4-dihydroxybenzophenone
- Cas Number:
- 131-56-6
- Molecular formula:
- C13H10O3
- IUPAC Name:
- 4-benzoylbenzene-1,3-diol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: albino
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- abraded
- Vehicle:
- other: see below
- Amount / concentration applied:
- 0.5 ml test solution on the patch.
Concentrations of the test substance in the test solution were 4, 8 and 16% in petrolatum, respectively dimethyl phthalate - Duration of treatment / exposure:
- 24 h
- Observation period:
- 24h and 48h (immediately after patch removal and 24 hours after patch removal)
- Number of animals:
- 6
- Details on study design:
- Scoring according to Draize
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24h
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- other: not applicable (no effects seen)
- Remarks on result:
- other: application of upto a concentration of 16% of the test substance in petrolatum
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 0.25
- Max. score:
- 8
- Reversibility:
- fully reversible within: another 24 h
- Remarks on result:
- other: application of upto a concentration of 16% of the test substance in dimethyl phthalate. Effect was only seen at 16%, not at 4% or 8%
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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