Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-029-4 | CAS number: 131-56-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Title:
- Final report on the safety assessment of benzophenones-1, -3, -4, -5, -9, and -11
- Author:
- Anonymous
- Year:
- 1 983
- Bibliographic source:
- Journal of the American College of Toxicology, Volume 2, Number 5 (1983), page 35-77
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- Draize
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2,4-dihydroxybenzophenone
- EC Number:
- 205-029-4
- EC Name:
- 2,4-dihydroxybenzophenone
- Cas Number:
- 131-56-6
- Molecular formula:
- C13H10O3
- IUPAC Name:
- 4-benzoylbenzene-1,3-diol
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: other eye of same animal
- Amount / concentration applied:
- 100 mg of the undiluted substance
- Duration of treatment / exposure:
- there was no eye wash
- Observation period (in vivo):
- daily for 7 days
- Number of animals or in vitro replicates:
- 6
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: day 1
- Score:
- 20
- Max. score:
- 110
- Remarks on result:
- other: In a second identical study the score was 17
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: day 2
- Score:
- 7
- Max. score:
- 110
- Remarks on result:
- other: In a second identical study the score was 15
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: day 3
- Score:
- 0
- Max. score:
- 110
- Remarks on result:
- other: In a second identical study the score was 10.3
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: day 4
- Score:
- 0
- Max. score:
- 110
- Remarks on result:
- other: In a second identical study the score was 3
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: day 5
- Score:
- 0
- Max. score:
- 110
- Remarks on result:
- other: In a second identical study the score was 0
Applicant's summary and conclusion
- Interpretation of results:
- Category 2B (mildly irritating to eyes)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
