Registration Dossier
Registration Dossier
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EC number: 205-029-4 | CAS number: 131-56-6
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Link to relevant study records
- Endpoint:
- fertility, other
- Remarks:
- based on test type (migrated information)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Guideline:
- other: review article
- GLP compliance:
- not specified
- Species:
- rat
- Sex:
- female
- Route of administration:
- other: oral, subcutaneous and intra-peritoneal
- Duration of treatment / exposure:
- 3 days
- Dose descriptor:
- NOAEL
- Effect level:
- 100 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: see 'Remark'
- Reproductive effects observed:
- not specified
Reference
Effect on fertility: via oral route
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- NOAEL
- 100 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
Note that the NOAEL of 100 mg/kg/d was with intra-peritoneal application.
With subcutaneous application a NOAEL of 250 mg/kg/d was observed.
Effects were also seen after oral application but unfortunately that study did not indicate the dosages used.
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
With a NOAEL for toxicity to reproduction of 100 mg/kg/day after intra-peritoneal application, respectively 250 mg/kg/day after subcutaneous application, the substance should be classified as reproductive toxicant Category 2 with H361 (suspected of damaging fertility)
Additional information
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