Registration Dossier
Registration Dossier
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EC number: 205-029-4 | CAS number: 131-56-6
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Title:
- Final report on the safety assessment of benzophenones-1, -3, -4, -5, -9, and -11
- Author:
- Anonymous
- Year:
- 1 983
- Bibliographic source:
- Journal of the American College of Toxicology, Volume 2, Number 5 (1983), page 35-77
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 2,4-dihydroxybenzophenone
- EC Number:
- 205-029-4
- EC Name:
- 2,4-dihydroxybenzophenone
- Cas Number:
- 131-56-6
- Molecular formula:
- C13H10O3
- IUPAC Name:
- 4-benzoylbenzene-1,3-diol
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA98/100/1535/1537/1538
- Metabolic activation:
- with and without
- Metabolic activation system:
- rat S9 fraction
- Test concentrations with justification for top dose:
- 0.1 to 500 microgram/plate
- Vehicle / solvent:
- DMSO
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: TA98/100/1535/1537/1538
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not determined
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
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