Registration Dossier
Registration Dossier
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EC number: 205-029-4 | CAS number: 131-56-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Guideline:
- other: Shelanski RIPT
- GLP compliance:
- not specified
- Type of study:
- other: human patch test
- Species:
- human
- Vehicle:
- other: butyl carbitol
- Concentration / amount:
- 1%
- Vehicle:
- other: butyl carbitol
- Concentration / amount:
- 1%
- No. of animals per dose:
- 100
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 25 microliter 0% (vehicle control), 1%, 10%, 25%, 50%
- No. of animals per dose:
- 5
- Positive control substance(s):
- hexyl cinnamic aldehyde (CAS No 101-86-0)
- Reading:
- other: no data
- Group:
- test chemical
- Dose level:
- 1% in butyl carbitol
- No. with + reactions:
- 0
- Total no. in group:
- 100
- Remarks on result:
- other: Reading: other: no data. Group: test group. Dose level: 1% in butyl carbitol. No with. + reactions: 0.0. Total no. in groups: 100.0.
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The substance was found not to be a sensitizer in a cohort of 100 humans
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