Registration Dossier
Registration Dossier
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EC number: 271-360-6 | CAS number: 68551-08-6
Biotransformation and kinetics
Administrative data
- Endpoint:
- biotransformation and kinetics
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Study period:
- 1999
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Abstract from Symposium
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Higher alcohols bioconcentration: Influence of Biotransformation
- Author:
- Watze De Wolf and Tom Parkerton
- Year:
- 1 999
- Bibliographic source:
- 217th ACS National Meeting, Anaheim,CA Symposium 'Persistent, Bioaccumulative, Toxic Chemicals'
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other:
- Deviations:
- yes
- Principles of method if other than guideline:
- Made use of OECD 305 guideline
- GLP compliance:
- yes
- Remarks:
- Stated in the abstract
- Type of medium:
- aquatic
Test material
- Reference substance name:
- Commercial branched chain alcohols of 10, 12 and 13 carbon atoms
- IUPAC Name:
- Commercial branched chain alcohols of 10, 12 and 13 carbon atoms
Constituent 1
Results and discussion
Any other information on results incl. tables
Water analysis showed that exposure concentrations were maintained relatively constant during the uptake phase. The uptake phase showed the fish attained rapid and steady state concentration of the alcohol. Rapid elimination occured after transfer to clean water. Measurement of the BCF values at the lower water concentration tested were 16, 29 and 30 for C10 , C12 and C13 -alcohol. Measured BCF values were dependant on water concentration with a two-fold increase observed for the C12 and C13 alcohol.
Applicant's summary and conclusion
- Conclusions:
- There is no specific conclusion on the bioconcentration factor in fish for Isoundecanol.
- Executive summary:
The results of bioconcentration testing in fish clearly showed lack of any substantial bioconcentration of the C10, C12 and C13 alcohols tested. The BCF value were 16, 29 and 30 , respectively. Isoundecanol (C11) is closely related to this group of alcohols, and although the information is taken from a scientific abstract, it is considered adequate to support the non PBT status of Isoundecanol.
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