Registration Dossier

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Acceptable, well-documented study report equivalent or similar to OECD guideline 403: pre-GLP.

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1960
Report date:
1960
Reference Type:
publication
Title:
Acute toxicity of a homologous series of branched chain primary alcohols
Author:
Scala RA & Burtis EG
Year:
1973
Bibliographic source:
Am Ind Hyg Assoc J 34:493-499

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Alcohols, C9-11-iso-, C10-rich
EC Number:
271-234-0
EC Name:
Alcohols, C9-11-iso-, C10-rich
Cas Number:
68526-85-2
Molecular formula:
CnH2n+1OH (n = 9 to 11)
IUPAC Name:
Branched alcohols, C9-11, C10 rich
Test material form:
liquid

Test animals

Species:
other: Swiss albino mice, Wistar rats, English short-hair guinea pigs
Strain:
other:
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data provided.

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Details on inhalation exposure:
Exposure was conducted in a 500 l stainless steel inhalation chamber equipped at the inlet with a device for generating a near-saturated vapor of the test material.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
ca. 6 h
Concentrations:
Theoretical chamber concentration was 95.3 ppm (~611 mg/m3)
No. of animals per sex per dose:
10 mice, 10 rats, 10 guinea pigs
Control animals:
no
Details on study design:
During the exposure period, all animals were observed for gross signs of toxicity at one-half hour intervals. At the end of the exposure period the animals were observed for a period of 24 hours.
Statistics:
Not applicable

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 95.3 ppm
Exp. duration:
6 h
Mortality:
None
Clinical signs:
other: Thirty minutes after initiation of the exposure, mice and rats exhibited blinking and redness around the nostrils. 150 minutes after initiation a slight nasal discharge and salivation were observed in the mice and rats. These signs persisted through the
Body weight:
Not assessed
Gross pathology:
Not assessed

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The acute inhalation LC50 for isodecanol is >95.3 ppm.
Executive summary:

Isodecanol was administered as a vapor to 10 male mice, rats, and guinea pigs at the theoretical concentration of 95.3 ppm for 6 hours.  During the exposure period all animals were observed for gross signs of toxicity every 30 minutes.  Thirty minutes after the initiation of the exposure, mice and rats exhibited blinking and redness around the nostril; eventually signs of nasal discharge and salivation were observed and persisted throughout the experiment.  All animals appeared normal within 30 minutes after termination of the exposure.   At the end of the study, the LC50 was > 95.3 ppm.

Categories Display