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EC number: 265-054-1 | CAS number: 64741-53-3 A complex combination of hydrocarbons produced by vacuum distillation of the residuum from atmospheric distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C20 through C50 and produces a finished oil with a viscosity of at least 100 SUS at 100°F (19cSt at 40°C). It contains relatively few normal paraffins.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable with restrictions because this publication was well-documented and adheres to basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- Feeding studies in rats with mineral hydrocarbon food grade white oils
- Author:
- Baldwin, M.K., Berry, P.H., Esdaile, D.J., Linnett, S.L., Martin, J.G., Peristianis, G.C., Priston, R.J., Simpson, B.J.E., Smith, J.D.
- Year:
- 1 992
- Bibliographic source:
- Toxicologic Pathology, 20(3) part 1:426-435
Materials and methods
- Objective of study:
- other: Measure of hydrocarbon residues in tissues
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- This study was conducted as a subchronic study, but tissues were examined for hydrocarbon residues.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Oleum-treated white oil and hydrotreated white oil
- IUPAC Name:
- Oleum-treated white oil and hydrotreated white oil
- Details on test material:
- C16 and C18 hydrocarbons that are constituents of the substance being registered.
- Name of test material (as cited in study report): Oleum-treated white oil and hydrotreated white oil
- Test substance: C16 and C18 hydrocarbons
- Physical state: Liquid
- Analytical purity: Not reported
- Impurities (identity and concentrations): Not reported
- Composition of test material, percentage of components: Not reported
- Lot/batch No.: Not reported
- Other: Both oils were derived from naphthenic crudes of different viscosities. The oleum-treated white oil was refined by oleum treatment following vacuum distillation of atmospheric residue (conventional refining). It has a specific gravity of 0.874 at 15 degrees Celsius and a viscosity of 26 mm2/second at 40 degrees Celsius. The hydrotreated white oil was produced by hydrotreatment of the vacuum distillate of an atmospheric residue. It has a specific gravity of 0.878 at 15 degrees Celsius and a viscosity of 69 mm2/second at 40 degrees Celsius.
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River, Manston, Kent
- Age at study initiation: 6 to 8 weeks old
- Weight at study initiation: Not reported
- Housing: Individually
- Individual metabolism cages: No
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Not reported
- Acclimation period: Not reported
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Not reported
- Humidity (%): Not reported
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): Not reported
IN-LIFE DATES: Not reported
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: "DISTOL"-grade hexane, Fisons
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS: Each test oil was dissolved in “DISTOL”-grade hexane, Fisons to make a premix, which was used to achieve homogeneous dispersal of the appropriate amount of test oil in each batch of test diet. Controls used solvent mixed in the diet.
DIET PREPARATION
- Rate of preparation of diet (frequency): Within 7 days
- Mixing appropriate amounts with (Type of food): Powdered laboratory rat diet, LAD2 (Special Diet Services, Witham, Essex)
- Storage temperature of food: Not reported
VEHICLE
- Justification for use and choice of vehicle (if other than water): not reported
- Concentration in vehicle: Not reported
- Lot/batch no. (if required): Not reported
- Purity: Not reported
HOMOGENEITY AND STABILITY OF TEST MATERIAL: Stated to be homogeneous, but there was no mention of stability. - Duration and frequency of treatment / exposure:
- 90 continuous days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0 or 20,000 ppm
- No. of animals per sex per dose / concentration:
- Five animals per sex were used per dose for tissue analysis
- Control animals:
- yes, plain diet
- Positive control reference chemical:
- None reported
- Details on study design:
- - Dose selection rationale: None reported
- Rationale for animal assignment (if not random): Not reported - Details on dosing and sampling:
- PHARMACOKINETIC STUDY (Absorption, distribution, excretion)
- Tissues and body fluids sampled: Liver and mesenteric lymph nodes
- Time and frequency of sampling: After 90 days of treatment
METABOLITE CHARACTERISATION STUDIES
- Tissues and body fluids sampled: Liver and mesenteric lymph nodes
- Time and frequency of sampling: After 90 days of treatment
- From how many animals: Five animals per sex per dose
- Method type(s) for identification: HPLC with refractive index detection
- Limits of detection and quantification: Not reported
- Other: Liver and mesenteric lymph nodes were tested for total hydrocarbon content.
- Statistics:
- None reported for toxicokinetic portion of the study.
Results and discussion
- Preliminary studies:
- The C16 and C18 hydrocarbons that are constituents of these oils are metabolized to the corresponding fatty acids of the same carbon chain length as the parent hydrocarbons, suggesting a process of omega oxidation.
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Absorption was not specifically measured. The data indicate absorption occurs, but there is no data on the amount of compound absorbed via oral administration.
- Details on distribution in tissues:
- Only the liver and mesenteric tissues were examined. The liver had greater levels of total hydrocarbons than the mesenteric lymph nodes, but females had higher levels in both tissues than the males.
- Details on excretion:
- Not examined
Metabolite characterisation studies
- Metabolites identified:
- not measured
- Details on metabolites:
- Only total hydrocarbons were measured.
Any other information on results incl. tables
No metabolism studies have been reported for unrefined / acid treated oils, but studies have been reported on the metabolism of C16 and C18 hydrocarbons that are constituents of these oils. In this study, it has been shown that the hydrocarbons are metabolised to the corresponding fatty acids of the same carbon chain length as the parent hydrocarbons, suggesting a process of omega oxidation.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no data
No metabolism studies have been reported for unrefined / acid treated oils but studies have been reported on the metabolism of C16 and C18 hydrocarbons that are constituents of these oils. In these studies it has been shown that the hydrocarbons are metabolised to the corresponding fatty acids of the same carbon chain length as the parent hydrocarbons, suggesting a process of omega oxidation. - Executive summary:
Justification for Read Across
C16 and C18 hydrocarbons that are constituents of the substance being registered.
No metabolism studies have been reported for unrefined / acid treated oils but studies have been reported on the metabolism of C16 and C18 hydrocarbons that are constituents of these oils. In these studies it has been shown that the hydrocarbons are metabolised to the corresponding fatty acids of the same carbon chain length as the parent hydrocarbons, suggesting a process of omega oxidation.
Based on study design and results, this study is classified as reliable with restrictions because this publication was well-documented and adheres to basic scientific principles.
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