Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 265-054-1 | CAS number: 64741-53-3 A complex combination of hydrocarbons produced by vacuum distillation of the residuum from atmospheric distillation of crude oil. It consists of hydrocarbons having carbon numbers predominantly in the range of C20 through C50 and produces a finished oil with a viscosity of at least 100 SUS at 100°F (19cSt at 40°C). It contains relatively few normal paraffins.
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
Worker DNEL:Unrefined Acid Treated Oils
|
Effect |
Route |
DNEL |
Dose Descriptor |
Modified Dose Descriptor and Assessment Factors |
Acute Exposure |
Systemic |
Dermal |
(a) |
|
|
Inhalation |
(a) |
|
|
||
Local |
Dermal |
(a) |
|
|
|
Inhalation |
(a) |
|
|
||
Long-Term Exposure |
Systemic (c) |
Dermal |
32 mg/kg/8h |
1000 mg/kg (NOAEL based on significant body weight loss.) |
Dose descriptor was modified to correct starting point of 248 mg/kg/8 hr by adjustments for dermal absorption and duration of exposure. Then AF of 43 was applied for inter- and intraspecies differences and for total duration. |
Inhalation |
2.7 mg/m3/8 h [aerosol] |
30 mg/kg (LOAEL based on systemic effects in dermal rat study read-across from Untreated Distillate Aromatic Extracts: change in adrenals and bone marrow toxicity in males) |
Dose descriptor was modified to correct starting point of 41mg/kg/8 hr by adjustments for dermal absorption, dermal to inhalation route and level of activity, LOAEL to NOAEL. Then AF of 15 was applied for inter- and intraspecies differences and for total duration. |
||
Local |
Dermal |
(a) for 13-wk exposures and (b) for chronic exposures (dermal carcinogen) |
|
|
|
Inhalation |
5.4 mg/m3/8h [aerosol] |
500 mg/m3(NOAEC based on respiratory effects such as focal infiltrations or inflammatory cells, focal hyperplasia, squamous metaplasia of the nasal mucosa read-across from other Lubricant Base oil <3%) |
Dose descriptor was modified to correct starting point of 251 mg/m3/8h by adjustment for duration of exposure and level of activity. Then AF of 45 was applied for inter- and intraspecies and total duration differences. |
a) No hazard identified for this route (data available)
b) No-threshold effect and/or no dose-response information available
c) Long-term systemic effects include non-reproductive effects and developmental/reproductive effects. Lowest DNEL is shown.
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
General Population DNEL: Unrefined Acid Treated Oils
|
Effect |
Route |
DNEL |
Dose Descriptor |
Modified Dose Descriptor and Assessment Factors |
Acute Exposure |
Systemic
|
Dermal |
(a) |
|
|
Inhalation |
(a) |
|
|
||
Local |
Dermal |
(a) |
|
|
|
Inhalation |
(a) |
|
|
||
Long-Term Exposure |
Systemic |
Dermal |
(a) |
|
|
Inhalation |
(a) |
|
|
||
Oral |
0.74 mg/kg/24 h (b) |
125 mg/kg (LOAEL based on systemic effects in oral rat study read-across from Untreated Distillate Aromatic Extracts: change in adrenals and bone marrow toxicity in males) |
Dose descriptor was modified to correct starting point of 30 mg/kg/24 h by adjustments for LOAEL to NOAEL and duration of exposure. Then AF of 40 was applied for inter- and intraspecies differences and for total duration. |
||
Local |
Dermal |
(a) |
|
|
|
Inhalation |
(a) |
|
|
a) No DNEL needed since no exposure expected
b) This substance is not used by the general population. This value is for indirect exposure assessment only.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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