Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 931-285-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian cell study: DNA damage and/or repair
- Remarks:
- Type of genotoxicity: DNA damage and/or repair
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable well-documented study report performed on an analgoue material under GLP conditions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 870.5915 (In Vivo Sister Chromatid Exchange Assay)
- GLP compliance:
- yes
- Type of assay:
- sister chromatid exchange assay
Test material
- Reference substance name:
- Naphtha (petroleum), light catalytic cracked
- EC Number:
- 265-056-2
- EC Name:
- Naphtha (petroleum), light catalytic cracked
- Cas Number:
- 64741-55-5
- IUPAC Name:
- Naphtha (petroleum), light catalytic cracked
- Reference substance name:
- Light catalytic cracked naphtha
- IUPAC Name:
- Light catalytic cracked naphtha
Constituent 1
Constituent 2
Test animals
- Species:
- mouse
- Strain:
- B6C3F1
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- corn oil
- Duration of treatment / exposure:
- 20 to 22 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
3 Test groups: 200, 1200 and 2400 mg/kg
Basis:
- No. of animals per sex per dose:
- 5/sex/dose
- Positive control(s):
- Positive control group: 10 mg/kg of cyclophosphamide.
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- positive
- Toxicity:
- no effects
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): positive
The in vivo sister chromatid exchange assay of light catalytic cracked naphtha (API 81-03) was positive. This finding alone does not warrant the classification of light catalytic cracked naphtha as a genotoxin under the new Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations. - Executive summary:
Light catalytic cracked naphtha (API 81-03) was examined for its potential to induce sister chromatid exchange in mouse bone marrow erythrocytes from mice dosed intraperitoneally with the test material for 20 or 22 hours at concentrations of 200, 1200, and 2400 mg/kg in corn oil. Vehicle control animals were dosed with clean air alone, and positive control animals were dosed intraperitoneally with 10 mg/kg of cyclophosphamide. The test substance induced a significant dose-dependent increase in bone marrow sister chromatid exchanges in B6C3F1 mice. No clinical signs of toxicity were observed. The in vivo sister chromatid exchange assay of light catalytic cracked naphtha (API 81-03) was positive. This finding alone does not warrant the classification of light catalytic cracked naphtha as a genotoxin under the new Regulation (EC) 1272/2008 on classification, labeling, and packaging of substances and mixtures (CLP) or under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
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