Triclocarban

Endpoint summary

Description of key information

Toxicity to soil microorganisms except arthropods:

Summarized result for the toxicity of test chemical were studied on the soil microorganisms. The studies are as mention below:

 

The first study was conducted to determine the effect of test chemical on Eisenia fetida. The Lethal effect concentration (LC50) value of test chemical to Eisenia fetida in a 48 hrs study was determine to be 40 mg/kg.

 

First study was supported by the second study from peer reviewed journal. The effects of test chemical were studied in the freshwater mudsnail Potamopyrgus antipodarum over 4 weeks were determined. Aquatic vegetation was collected in D-nets, and snails were removed and kept in river water in 1- gallon buckets for transfer to the laboratory. Within 2 h, snails were transferred into 10-gallon aquaria filled with artificial freshwater (Milli-Q water plus added salts at a rate of 5 g CaCO3, 5 g sea salt, and 0.5 g NaHCO3 per 10 gallons of water). After 3 to 5 d of acclimation to laboratory conditions, 60 individuals with shell lengths greater than 3.0 mm were transferred to each individual 1-L jar filled with 800 ml artificial freshwater. The jars were aerated through glass pipettes to keep dissolved oxygen near saturation. After four weeks, environmentally relevant test chemical concentrations of 1.6 to 10.5 mg/L resulted in statistically significant increases in the number of unshelled embryos, whereas 0.2, 1.6, and 10.5 mg/L exposures significantly increased numbers of shelled embryos. The lowest observed effect concentration (LOEC) was 0.2 mg/L, the no observed effect concentration (NOEC) was 0.05 mg/L; the 10% effective concentration (EC10) and the median effective concentration (EC50) for unshelled effects were 0.5 mg/L and 2.5 mg/L, respectively.

Toxicity to terrestrial arthropods:

Test chemical is used mostly as an anti-bacterial agent in cosmetics, disinfectants and soaps. None of these uses suggest direct or even indirect exposure to the soil compartment and therefore in accordance with column 2 of Annex IX, toxicity of test chemical to terrestrial arthropods was considered for waiver.

 

Toxicity to terrestrial plants:

Test chemical is used mostly as an anti-bacterial agent in cosmetics, disinfectants and soaps. None of these uses suggest direct or even indirect exposure to the soil compartment and therefore in accordance with column 2 of Annex IX, toxicity of test chemical to terrestrial plants was considered for waiver.

 

Toxicity to soil microorganisms:

Test chemical is used mostly as an anti-bacterial agent in cosmetics, disinfectants and soaps. None of these uses suggest direct or even indirect exposure to the soil compartment and therefore in accordance with column 2 of Annex IX, toxicity of Test chemical to soil micro-organisms was considered for waiver.

Additional information

Toxicity to soil microorganisms except arthropods:

Summarized result for the toxicity of test chemical were studied on the soil microorganisms. The studies are as mention below:

 

The first study was conducted to determine the effect of test chemical on Eisenia fetida. The Lethal effect concentration (LC50) value of test chemical to Eisenia fetida in a 48 hrs study was determine to be 40 mg/kg.

 

First study was supported by the second study from peer reviewed journal. The effects of test chemical were studied in the freshwater mudsnail Potamopyrgus antipodarum over 4 weeks were determined. Aquatic vegetation was collected in D-nets, and snails were removed and kept in river water in 1- gallon buckets for transfer to the laboratory. Within 2 h, snails were transferred into 10-gallon aquaria filled with artificial freshwater (Milli-Q water plus added salts at a rate of 5 g CaCO3, 5 g sea salt, and 0.5 g NaHCO3 per 10 gallons of water). After 3 to 5 d of acclimation to laboratory conditions, 60 individuals with shell lengths greater than 3.0 mm were transferred to each individual 1-L jar filled with 800 ml artificial freshwater. The jars were aerated through glass pipettes to keep dissolved oxygen near saturation. After four weeks, environmentally relevant test chemical concentrations of 1.6 to 10.5 mg/L resulted in statistically significant increases in the number of unshelled embryos, whereas 0.2, 1.6, and 10.5 mg/L exposures significantly increased numbers of shelled embryos. The lowest observed effect concentration (LOEC) was 0.2 mg/L, the no observed effect concentration (NOEC) was 0.05 mg/L; the 10% effective concentration (EC10) and the median effective concentration (EC50) for unshelled effects were 0.5 mg/L and 2.5 mg/L, respectively.

Toxicity to terrestrial arthropods:

Test chemical is used mostly as an anti-bacterial agent in cosmetics, disinfectants and soaps. None of these uses suggest direct or even indirect exposure to the soil compartment and therefore in accordance with column 2 of Annex IX, toxicity of test chemical to terrestrial arthropods was considered for waiver.

 

Toxicity to terrestrial plants:

Test chemical is used mostly as an anti-bacterial agent in cosmetics, disinfectants and soaps. None of these uses suggest direct or even indirect exposure to the soil compartment and therefore in accordance with column 2 of Annex IX, toxicity of test chemical to terrestrial plants was considered for waiver.

 

Toxicity to soil microorganisms:

Test chemical is used mostly as an anti-bacterial agent in cosmetics, disinfectants and soaps. None of these uses suggest direct or even indirect exposure to the soil compartment and therefore in accordance with column 2 of Annex IX, toxicity of Test chemical to soil micro-organisms was considered for waiver.