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EC number: 202-924-1
CAS number: 101-20-2
35 days long term fish toxicity study
was conducted to test the effects of test chemical on Pimephales
promelas. The No observed effect concentration (NOEC) value of test
chemical in 35 day study in Pimephales promelas was observed to be 0.005
mg/L on basis of effect on Hatchability of eggs, growth, and survival.
First study was supported by the
second study. Long term fish toxicity study was conducted to test the
effects of test chemical on danio rerio larvae in 9 days. At least three
replicates of 15 embryos were placed in 50 ml beaker for five
concentrations. The solutions were replaced every 48 h (i.e. a
semi-static system) and the concentration of the selected antimicrobials
was monitored using the HPLC as presented above. The DO and pH were also
monitored at the replacement of the solutions. The percentage hatching
and the survival rate of the larvae were evaluated until the egg yolk
had disappeared. The No observed effect concentration (NOEC) value of
test chemical in 9 day study in Danio rerio larvae was observed to be
0.024 mg/L on basis of effect on hatching and the survival of larvae.
Various long term studies available
for the test chemical were reviewed to determine the toxic nature of
test chemical on the mortality of fish. The studies are as mentioned
Aim of this study was to evaluate the
effect of test chemical on mortality of Pimephales promelas. Test
conducted under the flow-through system. The Low observed effect level
(LOEL) value of test chemical in 30 day study in Pimephales promelas on
basis of effect on mortality was determine to be 0.01 mg/L.
Similar 35 days long term fish
toxicity study was conducted to test the effects of test chemical on
pimpheles promelas. No treatment related effects were observed at the
used concentrations. The No observed effect concentration (NOEC) of test
chemical in 35 day study in Pimephales promelas on basis of effect on
egg hatchability or growth of the fry was observed to be 0.005 mg/L.
Thus based on the above results,
chemical consider to be toxic and classified in aquatic chronic category
2 as per the CLP classification criteria.
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