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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Data is from computational model developed by USEPA and secondary source
Qualifier:
according to
Guideline:
other: Modeling database
Principles of method if other than guideline:
HYDROWIN Program (v2.00) from EPI Suite estimation database
GLP compliance:
not specified
Radiolabelling:
not specified
Analytical monitoring:
not specified
Estimation method (if used):
HYDROWIN v2.00
Positive controls:
not specified
Negative controls:
not specified
Transformation products:
not specified
Key result
Temp.:
25 °C
DT50:
> 1 yr
Type:
other: estimated data
Remarks on result:
other: Other details not known

HYDROWIN Program (v2.00) Results:

================================

SMILES : O=C(Nc(ccc(c1)CL)c1)Nc(ccc(c2CL)CL)c2

CHEM : Urea, N-(4-chlorophenyl)-N'-(3,4-dichlorophenyl)-

MOL FOR: C13 H9 CL3 N2 O1

MOL WT : 315.59

--------------------------- HYDROWIN v2.00 Results ---------------------------

Hydrolyzable Function detected: Urea (Normal)

R-N-C(=O)-N-R

(where R is an alkyl, aromatic carbon or hydrogen substituent(s))

These types of ureas hydrolyze slowly with half-lives generally > 1 year.

See the on-line User Guide help file for experimental rate data of

normal urea pesticides.

Validity criteria fulfilled:
not specified
Conclusions:
The estimated half-life of test chemical was evaluated to be > 1 yr (at 25ᵒC) respectively, indicating that it is not hydrolysable in water.
Executive summary:

HYDROWIN v2.00 program of Estimation Programs Interface (2018) prediction model was used to predict the hydrolysis half-life of test chemical. The estimated half-life of test chemical was evaluated to be > 1 yr (at 25ᵒC) respectively, indicating that it is not hydrolysable in water.

Description of key information

HYDROWIN v2.00 program of Estimation Programs Interface (2018) prediction model was used to predict the hydrolysis half-life of test chemical (Modelling database, 2018 and secondary source, 2002). The estimated half-life of test chemical was evaluated to be > 1 yr (at 25ᵒC) respectively, indicating that it is not hydrolysable in water.

Key value for chemical safety assessment

Half-life for hydrolysis:
1 yr
at the temperature of:
25 °C

Additional information

HYDROWIN v2.00 program of Estimation Programs Interface (2018) prediction model was used to predict the hydrolysis half-life of test chemical (Modelling database, 2018 and secondary source, 2002). The estimated half-life of test chemical was evaluated to be > 1 yr (at 25ᵒC) respectively, indicating that it is not hydrolysable in water.

Hydrolysis endpoint can also be considered for waiveras per in accordance with column 2 of Annex VIII of the REACH regulation, testing for this endpoint is scientifically not necessary and does not need to be conducted since the test chemical is readily biodegradable.