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EC number: 202-924-1
CAS number: 101-20-2
To evaluate the effect of test
chemical on the domestic sewage by providing the exposure period of 16
days. Domestic sewage was obtain ocean County South Treatment Plant
Test. Anaerobic Digester Inhibition test was performed. After the
exposure period of 16 days, effect of test chemical on the domestic
sewage were determine. The NOEC was determine to be at 100 mg/l.
Toxicity to microorganisms:
The MIC values were determined by the
microbroth dilution assay according to the National Committee for
Clinical Laboratory Standards methods for antimicrobial susceptibility
tests for aerobically growing bacteria (Approved Standard M7-A2, NCCLS,
Villanova, PA, 1990).
Approximately 6.5 3 108 cells of strain
RN4220 (25) were plated on to brain-heart infusion agar medium
(Becton-Dickinson) containing 0.5 mg/ml test material. The plates were
incubated at 37 °C with periodic monitoring. After 48 h, resistant
clones were picked and their phenotype confirmed by regrowth on the
original selective concentration of test material.
Three strains of Staphylococcus aureus
namely RN4220 (wild-type) , RN4220/pTri-1 , GR664 (fabIG23S) and three
starins of E.coli
W3110 (wild-type) , W3110/pFabI , RJH108
(fabIG93V) . The wild-type FabI proteins from either S. aureus or E.
coli were expressed using plasmids pTri-1 or pFabI, respectively, to
determine if resistance was conferred by the presence of multiple copies
of the fabI genes.
The minimum ihhibition concentration (MIC)
was observed in the range of 0.25 to 2 mg/l in case of Staphylococcus
aureus and for E.Coli MIC was observed in concentration range of 0.5 -
In another secondary data for test chemical
the effect of test chemical on the domestic sewage by providing the
exposure period of 16 days. Domestic sewage was obtain ocean County
South Treatment Plant Test. Anaerobic Digester Inhibition test was
performed. After the exposure period of 16 days, effect of test chemical
on the domestic sewage were determine. The NOEC was determine to be at
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