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Diss Factsheets
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EC number: 202-924-1 | CAS number: 101-20-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal
- Justification for type of information:
- Data is from peer reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- Long term toxicity of test chemical were studied and determine on the reproduction of daphnia magna.
- GLP compliance:
- no
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- - Common name: Water flea
- Test type:
- not specified
- Water media type:
- freshwater
- Total exposure duration:
- 21 d
- Reference substance (positive control):
- not specified
- Key result
- Duration:
- 21 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 0.005 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other: Other details not known
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The LOEC was observed to be 0.0047 mg/L for 21 days based on the effect on reproduction.
- Executive summary:
Long term toxicity of test chemical were studied and determine on the reproduction of daphnia magna. The LOEC was observed to be 0.0047 mg/L for 21 days based on the effect on reproduction.
Reference
Description of key information
Long term toxicity of test chemical were studied and determine on the reproduction of daphnia magna. The LOEC was observed to be 0.0047 mg/L for 21 days based on the effect on reproduction.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.005 mg/L
Additional information
Based on the various long term studies available for the test chemical, studies were reviewed to determine the toxic nature of test chemical on the mobility and reproduction of aquatic invertebrates. The studies are as mentioned below:
In the first long term toxicity of test chemical were studied and determine on the reproduction of daphnia magna. The LOEC was observed to be 0.0047 mg/L for 21 days based on the effect on reproduction.
Above study was supported by the below study from peer reviewed journal. 8 days long term toxicity studies were conducted to test the effect of chemical on ceriodaphnia .Five concentrations and blanks were prepared with dechlorinated tap water for each antimicrobial test, and the survival and the number of neonates was counted for eight days, when most of the Ceriodaphnia had finished delivering three broods. The solutions were replaced every 48 h (i.e. a semi-static system) and the concentration before and after the replacement was analyzed using the HPLC. Only the numbers of first three broods were counted and compared with the blanks. Multiple comparisons were conducted to determine NOEC values as presented above for the algal test. After the exposure period of 8 days of chemical with Ceriodaphnia, no effect were observed on the survival rate and reproduction rate of Ceriodaphnia at the concentration 0.0019 mg/l. Thus based on the NOEC value chemical consider to be toxic and classified as aquatic chronic 1 as per the CLP classification criteria.
Similar long term toxicity of test chemical were studied on Americamysis bahia. Test conducted under the flow- through system for 28 days. The effective concentration (EC50) value of test chemical in Americamysis bahia(Opossum Shrimp) in a 28 days study based on growth was observed to be > 0.001 mg/L. Thus considering the value from CLP Criteria for aquatic classification of the substance, it is concluded that test chemical could exhibit short term toxicity to aquatic invertebrate (Americamysis bahia) and classified in Aquatic chronic category 1.
Aim of this study was to determine the effect of test chemical on the aquatic invertebrates. Test conducted under the flow-through system in which effect of chemical were tested by observing the effect of chemical on mortality and survival rate of daphnia magna. The Low observed effect concentration (LOEC) of test chemical on Daphnia magna in 21 days study on the basis of effect on mortality was determine to be 0.05 mg/L.
In the fifth study from secondary source, 21 days long term toxicity studies were conducted to test the effect of test chemical on daphnia magna. The NOEC was observed to be 0.0029 mg/L for 21 days based on the effect on reproduction.
Thus based on the overall studies from peer reviewed journal, authoritative database and secondary sources, chemical consider to be toxic and classified as aquatic chronic 1 as per the CLP classification criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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