Triclocarban

Endpoint summary

Description of key information

Bioaccumulation: aquatic/sediments:

The bioaccumulation test was conducted for 28 days for determination the bioconcentration factor (BCF) of chemical on test organism Cyprinus carpio. Nominal concentrations used in the study are Nominal concentrations 1st Concentration area : 0.020 mg/L, 2nd Concentration area : 0.0020 mg/Land Range finding study was carried out on Rice fish (Oryzias latipes) LC50(96h) > 5.0 mg/L,. The vehicle used in this study was HCO-40.The bioconcentration factor (BCF) for test chemical was determined in Cyprinus carpio . The lipid concentration was 3.6% at start of exposure and 3.4 % at end of exposure. The bioconcentration factor (BCF) for test chemical was determined in Cyprinus carpio. The BCF value was observed to be in range 63-93 L/kg and 80 L/kg at steady state at dose concentration 0.02 mg/L and in range 61-98 L/kg and 81 L/kg at steady state at dose concentration 0.002 mg/L. On the basis of total lipid content on test organism Cyprinus carpio during 28 days period. Therefore it is concluded that this test chemical is nonbioaccumulative.

Additional information

Bioaccumulation: aquatic/sediments:

Two experimental studies have been reviewed to determine bioconcentration factor of test chemical from different sources and their results are summarized below.

In first study the bioaccumulation test was conducted for 28 days for determination the bioconcentration factor (BCF) of chemical on test organism Cyprinus carpio. Nominal concentrations used in the study are Nominal concentrations 1st Concentration area : 0.020 mg/L, 2nd Concentration area : 0.0020 mg/Land Range finding study was carried out on Rice fish (Oryzias latipes) LC50(96h) > 5.0 mg/L,. The vehicle used in this study was HCO-40.The bioconcentration factor (BCF) for test chemical was determined in Cyprinus carpio . The lipid concentration was 3.6% at start of exposure and 3.4 % at end of exposure. The bioconcentration factor (BCF) for test chemical was determined in Cyprinus carpio. The BCF value was observed to be in range 63-93 L/kg and 80 L/kg at steady state at dose concentration 0.02 mg/L and in range 61-98 L/kg and 81 L/kg at steady state at dose concentration 0.002 mg/L. On the basis of total lipid content on test organism Cyprinus carpio during 28 days period. Therefore it is concluded that this test chemical is nonbioaccumulative.

In another study the Bioconcentration factor of test chemical was determined in Blue gill fish by flow through system for 30 days. Test chemical concentration used in the study was 0.72µg/L. The depuration duration of this study was 8 days. In this study population of approximately 80 bluegill (Lepomis macroiborius), 5 cm length, were exposed to a nominal test chemical concentration of 1.0µg/L.ina flow through system .The test chemical was 3.4 ring labelled HC with a specific activity of 4.54 mCi/mM (Monsanto Code 103). The bluegills were exposed for 30 days of uptake and 8 days of depuration. Fish were sampled on days 2, 7, 14, 22, 24, and 30 of uptake and on days of depuration. On each sampling day some fish were left whole and others were dissected into muscle, gills, intestines, liver, gall bladder, spleen, and remains. Dissected fish were pooled, two fish per observation with two observations in each mean estimate. All fish were dried, weighed combusted to carbon dioxide, and counted for 1C activity. The BCF value was determined to be 887 wt/wt. in whole fish. By considering this BCF value it is concluded that test chemical is non-bioaccumulative in blue gill fish.

By considering results of both the studies mentioned above it is observed that bioaccumulation concentration factor (BCF) in blue gill and cyprinus carpio fish was in range of 61- 887 L/Kg which is less than 2000. On the basis this range BCF value it is concluded that test chemical is non bioaccumulative in nature according to CLP classification criteria.