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EC number: 454-800-3 | CAS number: -
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- 1.54 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 2.3 - <= 2.6
- Conclusions:
- The water solubility of 2-chloro-5-chloromethylpyridine was determined as 1.54 g/L at 20°C.
- Executive summary:
The water solubility of 2-chloro-5-chloromethylpyridine in bidistilled water has been determined according to the "flask method" described in guideline 92/69/EEC, appendix A.6 and OECD-guideline 105.
Three weighed amounts of the test item were added to 10 mL bidistifled water and stirred at 30°C and different time intervals (24, 48 and 72 h). After equilibration (24 h at 20°C) aliquots of the saturated aqueous phase were filtered (Schleicher + Schull, 0.2 µm). 1 mL of each filtrate was than filled up with acetonitrile to a volume of 100 mL. The concentration of the test item was determined by HPLC.
A second experiment was performed according to this procedure but without test item ("blank"). The water solubility of 2-chloro-5-chloromethylpyridine was determined as 1.54 g/L at 20°C.
Reference
Description of key information
The water solubility of 2-chloro-5-chloromethylpyridine in bidistilled water has been determined according to the "flask method" described in guideline 92/69/EEC, appendix A.6 and OECD-guideline 105.
Three weighed amounts of the test item were added to 10 mL bidistifled water and stirred at 30°C and different time intervals (24, 48 and 72 h). After equilibration (24 h at 20°C) aliquots of the saturated aqueous phase were filtered (Schleicher + Schull, 0.2 µm). The concentration of the test item was determined by HPLC. The water solubility of 2-chloro-5-chloromethylpyridine was determined as 1.54 g/L at 20°C.
Key value for chemical safety assessment
- Water solubility:
- 1.54 g/L
- at the temperature of:
- 20 °C
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