Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Very old studies. No guidelines followed. Severe deficiencies to todays standards. Only secondary literatur available.

Data source

Reference
Reference Type:
secondary source
Title:
BUA Stoffbericht 55: Chlortoluidine (3-Chlor-2-methylanilin, 5-Chlor-2-methylanilin, 3-Chlor-4-methylanilin)
Author:
BUA Beratergremium für umweltrelevante Altstoffe
Year:
1990
Bibliographic source:
Verlag Chemie Weinheim 1991

Materials and methods

Test guideline
Qualifier:
no guideline available
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-chloro-o-toluidine
EC Number:
201-756-6
EC Name:
3-chloro-o-toluidine
Cas Number:
87-60-5
Molecular formula:
C7H8ClN
IUPAC Name:
3-chloro-2-methylaniline

Test animals

Species:
cat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
other: Oil, not further specified and no vehicle
Doses:
119 + 298 mg/kg

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
other: not specified
Effect level:
119 mg/kg bw
Remarks on result:
other: acute signs of intoxication but animals survived
Sex:
not specified
Dose descriptor:
other: not specified
Effect level:
298 mg/kg bw
Remarks on result:
other: Animal died within 23 h.

Any other information on results incl. tables

The intoxication symptoms seem to be predominantly caused by cyanosis.

Applicant's summary and conclusion