Registration Dossier

Diss Factsheets

Administrative data

Description of key information

The studies on oral toxicity are reliable. For dermal exposure there are only very old datas with doubtable reliability available. Since there are several hints that the substance can be resorbed percutaneous and enteral and because it is known that the substance causes cyanosis a precautionary classification as harmful in contact with skin is justified.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Dose descriptor:
681 mg/kg bw

Additional information

Justification for classification or non-classification

There are reliable studies on oral toxicity. Studies on dermal and subcutaneous toxicity are very old and because of this not very reliable. Nevertheless this results combined with fact that chlortoluidines can be absorbed through the skin and cause cyanosis (like anilines) a classification as harmful if swallowed and in contact to skin can be justified.