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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Well documented guideline study under GLP-Conditions

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1986
Reference Type:
secondary source
Title:
BUA Stoffbericht 55: Chlortoluidine (3-Chlor-2-methylanilin, 5-Chlor-2-methylanilin, 3-Chlor-4-methylanilin)
Author:
BUA Beratergremium für umweltrelevante Altstoffe
Year:
1990
Bibliographic source:
Verlag Chemie Weinheim 1991

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Qualifier:
according to guideline
Guideline:
EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Reference substance name:
3-Chlor-2-methylanilin
IUPAC Name:
3-Chlor-2-methylanilin
Constituent 2
Chemical structure
Reference substance name:
3-chloro-o-toluidine
EC Number:
201-756-6
EC Name:
3-chloro-o-toluidine
Cas Number:
87-60-5
Molecular formula:
C7H8ClN
IUPAC Name:
3-chloro-2-methylaniline

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
0.5 ml
Duration of treatment / exposure:
3 min. + 4h
Observation period:
72 h
Number of animals:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 30-60 min.
Score:
2
Max. score:
4
Reversibility:
fully reversible within: 72 h
Remarks on result:
other: Duration of Treatment : 3 min.
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24 h
Score:
2
Max. score:
4
Reversibility:
fully reversible
Remarks on result:
other: Duration of Treatment : 3 min.
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 48 h
Score:
2
Max. score:
4
Reversibility:
fully reversible
Remarks on result:
other: Duration of Treatment : 3 min.
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 72 h
Score:
0
Max. score:
4
Reversibility:
fully reversible
Remarks on result:
other: Duration of Treatment : 3 min.
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 30-60 min
Score:
0
Max. score:
4
Reversibility:
fully reversible
Remarks on result:
other: Duration of Treatment : 3 min.
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24 h
Score:
1
Max. score:
4
Reversibility:
fully reversible
Remarks on result:
other: Duration of Treatment : 3 min.
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 48 h
Score:
1
Max. score:
4
Reversibility:
fully reversible
Remarks on result:
other: Duration of Treatment : 3 min.
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 72 h
Score:
0
Max. score:
4
Reversibility:
fully reversible
Remarks on result:
other: Duration of Treatment : 3 min.
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 30-60 min
Score:
2
Max. score:
4
Reversibility:
fully reversible within: 14 d
Remarks on result:
other: Duration of Treatment : 4 h.
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24 h
Score:
2
Max. score:
4
Reversibility:
fully reversible within: 14 d
Remarks on result:
other: Duration of Treatment : 4 h.
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 48
Score:
2
Max. score:
4
Reversibility:
fully reversible within: 14 d
Remarks on result:
other: Duration of Treatment : 4 h.
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 72 h
Score:
3
Max. score:
4
Reversibility:
fully reversible within: 14 d
Remarks on result:
other: Duration of Treatment : 4 h.
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 7 d
Score:
2
Max. score:
4
Reversibility:
fully reversible within: 14 d
Remarks on result:
other: Duration of Treatment : 4 h.
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 14 d
Score:
0
Max. score:
4
Reversibility:
fully reversible
Remarks on result:
other: Duration of Treatment : 4 h.
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 30-60 min.
Score:
2
Max. score:
4
Reversibility:
fully reversible within: 14 d
Remarks on result:
other: Duration of Treatment : 4 h.
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 48 h
Score:
2
Max. score:
4
Reversibility:
fully reversible within: 14 d
Remarks on result:
other: Duration of Treatment : 4 h
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 7d
Score:
1
Max. score:
4
Reversibility:
fully reversible within: 14 d
Remarks on result:
other: Duration of Treatment : 4 h

Any other information on results incl. tables

After exposition (3 min./4 h) the testsubstance was removed by handwarm water. Under this conditions skin corrosion was observed.

Applicant's summary and conclusion

Interpretation of results:
corrosive
Remarks:
Migrated information Criteria used for interpretation of results: EU