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Diss Factsheets

Administrative data

Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Old study without GLP, but reliable.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Study of acidity constants of 3-, 4-, 5-, and 6-chloro-o-toluidinium ions in aqueous solutions and related thermodynamic quantities.
Author:
Gandhi & Patel
Year:
1970
Bibliographic source:
Bull. Chem. Soc. Jap. 455-459
Reference Type:
secondary source
Title:
BUA Stoffbericht 55: Chlortoluidine (3-Chlor-2-methylanilin, 5-Chlor-2-methylanilin, 3-Chlor-4-methylanilin)
Author:
BUA Beratergremium für umweltrelevante Altstoffe
Year:
1990
Bibliographic source:
Verlag Chemie Weinheim 1991

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: pH-measures
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-chloro-o-toluidine
EC Number:
201-756-6
EC Name:
3-chloro-o-toluidine
Cas Number:
87-60-5
Molecular formula:
C7H8ClN
IUPAC Name:
3-chloro-2-methylaniline

Results and discussion

Dissociating properties:
yes
Dissociation constant
No.:
#1
pKa:
3.62
Temp.:
25 °C
Remarks on result:
other: Corresponding conjugated acid in water. This results in a pKb-value of 10.39.

Applicant's summary and conclusion