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EC number: 931-338-5 | CAS number: 90622-77-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From Aug. 30, 2010 to Sept. 08, 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Remarks:
- The relative standard deviation of six replicates exceeds the limit (≤15%), but the TOC analysis was considered as acceptable (see 'Any other information on results incl. tables' for further details)
- Principles of method if other than guideline:
- Not applicable
- GLP compliance:
- not specified
- Type of method:
- flask method
- Water solubility:
- 36 mg/L
- Temp.:
- 20 °C
- pH:
- 7.9 - 8.4
- Details on results:
- - Water solubility of the test substance calculated via total organic carbon (TOC) at 20˚C is 36 mg/L.
- pH value of the sample solution was 7.9, 8.1, and 8.4 after 24, 48 and 72 h of incubation respectively. - Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
Under the test conditions, the water solubility of 'amides, C12-18(even-numbered) and C18(unsatd.), N-(hydroxyethyl)' was determined to be 36 mg/L at 20 °C (i.e., slightly soluble). - Executive summary:
A study was performed to determine the water solubility of ‘amides, C12-18(even-numbered) and C18(unsatd.), N-(hydroxyethyl)’ according to the EU Method A.6.
A preliminary experiment performed with the test substance showed high water solubility of above 10E-2 g/L. Hence, the water solubility was determined by the "shake flask method".
0.1773 g of the test substance (0.1561 g, 0.1197 g) was transferred to 100 mL of water and stirred in a heated water bath for 24 hours (48 hours, 72 hours) at 30˚C. After incubation, the sample suspension was cooled to 20˚C and stirred for 24 hours. The supernatant was then filtered using a syringe filter. After centrifugation (for 20 minutes, 4500 rpm) the clear supernatant was analyzed via TOC (Total organic carbon) method.
Under the test conditions, the water solubility of ‘amides, C12-18(even-numbered) and C18(unsatd.), N-(hydroxyethyl)’ was determined to be 36 mg/L at 20 °C (i.e., slightly soluble).
Reference
Table 1: Water solubility study results
The concentrations of the different test solutions were calculated automatically using the equation of the calibration curve and considering the dilution factors of the test solutions. The results are listed in the following table (all results given in mg/L):
Incubation time (hours)
|
Water solubility (TOC mg/L)
|
Total Average (TOC mg/L)
|
24 |
35 |
36 |
48 |
42 |
|
72 |
30 |
* standard deviation: 6.0 mg/L; relative standard deviation: 17.0%
- The relative standard deviation of six replicates exceeds the limit (≤15%) according to the test procedure. However, as the test substance was identified as a heterogenous mixture (with wide range of polarities) as per the GCMS chromatogram, a more accurate determination was not considered possible. Hence, the TOC analysis was considered as the appropriate technique to quantify the analyte in aqueous solution, and the relative standard deviation of 17% was considered to be acceptable.
Description of key information
The water solubility was determined according to EU Method A.6 (Frischmann, 2010).
Further water solubility testing according to OECD Guideline 105 is planned.
Key value for chemical safety assessment
- Water solubility:
- 36 mg/L
- at the temperature of:
- 20 °C
Additional information
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