Sodium 5-oxo-L-prolinate

Surface tension

Description of key information

Surface tension =  72.1 mN/m at 20°C, OECD 115, EU Method A. 5, Ring method, Sárvári 2012d.

Key value for chemical safety assessment

Surface tension:

72.1

in mN/m at 20°C and concentration in mg/L:

1 010

Additional information

The key study (Sárvári, 2012d) was performed under GLP conditions and in accordance with standardised guidelines. The study was assigned a reliability score of 1 in line with the principles for assessing data quality as defined by Klimisch (1997). Under the conditions of the study, the surface tension of the test material was determined to be 72.1 mN/m at 20 ºC in a 1010 mg/L solution. Since the surface tension was > 60 mN/m the test material is not considered to be surface active.

The supporting study (Butler, 2008) was performed using information on the read across substance, sodium 5-oxo-DL-prolinate, which is a racemic mixture of the D- and L- isomeric forms of the substance. Read-across is considered to be suitable based on the structural similarities between the read across substance (sodium 5-oxo-DL-prolinate) and the substance to be registered (sodium 5-oxo-L-prolinate), which is the L- isomer only. As such the difference in isomeric forms of the substance is unlikely to affect the physico-chemical properties. The study was conducted under GLP conditions and in accordance with standardised guidelines. The study was assigned a reliability score of 2 in line with the principles for assessing data quality as defined by Klimisch (1997). Under the conditions of the study, the surface tension of the test material was determined to be 69.3 mN/m at 22.4 ºC. Since the surface tension was > 60 mN/m the test material is not considered to be surface active. The results of this study are in good agreement, and support, the findings of the key study.