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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Link to relevant study record(s)

Description of key information

Estimation of the acid base properties based on the chemical structure.
General Physical Chemistry, Schering AG, Berlin. Study report A11216 (ADP_322), dated 2002-11-21
Hydroxydrospirenone is considered as a neutral molecule in the biologically relevant range of pH 2 to pH 12.

Key value for chemical safety assessment

Additional information

Hydroxydrospirenone does not contain any functional group, except of the aliphatic OH-group, which can be protonated or deprotonated significantly in aqueous solution.

For the aliphatic hydroxyl group a pKa value of 14.0 was calculated with the computer program ACD/pKa DP (Advanced Chemistry Development Inc. Toronto, Canada.

Therefore, Hydroxydrospirenone is to be considered as a neutral molecule in the pH range 2 – 10, which is of relevance for aqueous biological systems.