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Administrative data

Key value for chemical safety assessment

Additional information

ZK 90965 did not show a mutagenic potential in a bacterial reverse mutation assay / Ames test in 5 strains of S. typhimurium (TA98, TA100, TA1535, TA1537 and TA1538), when tested up to the highest recommended dose level of 5.0 mg/plate in the absense or presense of extrinsic metabolic activation (liver S9 mix from Aroclor 1254 -treated rats). Precipitates were seen at > 2.5 mg/plate.

Short description of key information:
Gene mutation (Bacterial reverse mutation assay / Ames test, GLP, OECD TG 471): negative with and without metabolic activation
[Schering AG, Report No. B195, 1999-08-02]

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Not classified according to EEC and GHS criteria since no genotoxic potential in vitro (Ames test).