Registration Dossier
Registration Dossier
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EC number: 255-911-8 | CAS number: 42613-21-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 03.05.2002-13.05.2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 112926-00-8
- EC Number:
- 601-214-2
- Cas Number:
- 112926-00-8
- IUPAC Name:
- 112926-00-8
- Details on test material:
- - Name of test material (as cited in study report): Syloid C 803
- Substance type: SiO2
- Physical state: white powder
- Stability under test conditions: stable
- Storage condition of test material: room temperature
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 0.1 g of Syloid C 803 was placed into the conjunctival sac of the right eye. 24 h after administration the eye was carefully rinsed with NaCl 0.9 % in order to remove the test substance.
- Observation period (in vivo):
- 5 days
- Number of animals or in vitro replicates:
- 3
Results and discussion
Any other information on results incl. tables
No rabbit shows swelling of lids or any redness of conjunctivae. No changes of the iris could be noted in all animals. Opacity of the cornea could be observed in none of the animals. In the untreated left eye, which served as a control, pathological symptoms could not be noted. After the adminsitration of 0.1 g test substance to the right eye, none of the treated animals died during the experiment or observation period. Systemic toxicological symptoms could not be observed.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
