Silicic acid, titanium salt

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: comparable to guideline study with acceptable restrictions.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Principles of method if other than guideline:

Application to the intact and abraded skin. Post observation period 48 h. Treatment sites were evalutated for signs of erythema and edema according to the Draize scoring system.

GLP compliance:

no

Test type:

fixed dose procedure

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

112926-00-8

EC Number:

601-214-2

Cas Number:

112926-00-8

IUPAC Name:

112926-00-8

Details on test material:

- Name of test material (as cited in study report): Syloid 244
- Substance type: powder
- Physical state: fine white powder

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

not specified

Administration / exposure

Type of coverage:

occlusive

Vehicle:

not specified

Duration of exposure:

24 h

Doses:

2000 mg/kg bw

No. of animals per sex per dose:

5

Control animals:

no

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Remarks on result:

other: maximum Draize score = 0

Any other information on results incl. tables

No deaths were noted up to 48 h after application. The dermal LD50 in the rabbit is greater than 2000 mg/kg bw. No changes in skin condition were noted in any animal during the test period.