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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: comparable to guideline study with acceptable restrictions.
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Principles of method if other than guideline:
Application to the intact and abraded skin. Post observation period 48 h. Treatment sites were evalutated for signs of erythema and edema according to the Draize scoring system.
GLP compliance:
no
Test type:
fixed dose procedure
Limit test:
yes

Test material

Constituent 1
Reference substance name:
112926-00-8
EC Number:
601-214-2
Cas Number:
112926-00-8
IUPAC Name:
112926-00-8
Details on test material:
- Name of test material (as cited in study report): Syloid 244
- Substance type: powder
- Physical state: fine white powder

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
not specified

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Duration of exposure:
24 h
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Remarks on result:
other: maximum Draize score = 0

Any other information on results incl. tables

No deaths were noted up to 48 h after application. The dermal LD50 in the rabbit is greater than 2000 mg/kg bw. No changes in skin condition were noted in any animal during the test period.

Applicant's summary and conclusion