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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Study period:
20 Jul 1984-15 Oct 1985
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: comparable to guideline study with acceptable restrictions
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report date:
1987

Materials and methods

Objective of study:
distribution
Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD 413
GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
112945-52-5
EC Number:
601-216-3
Cas Number:
112945-52-5
IUPAC Name:
112945-52-5
Constituent 2
Reference substance name:
Silica, amorphous, fumed
IUPAC Name:
Silica, amorphous, fumed
Details on test material:
- Name of test material (as cited in study report): Aerosil 200
- Analytical purity: > 99.8%
Radiolabelling:
no

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: aerosol
Vehicle:
unchanged (no vehicle)
Duration and frequency of treatment / exposure:
6 h/day, 5 days/week for 13 weeks
Doses / concentrations
Remarks:
Doses / Concentrations:
1.3, 5.9 or 31 mg/m3 (analytical concentration)
No. of animals per sex per dose / concentration:
no data
Control animals:
yes

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on distribution in tissues:
Silica could be detected in lungs only in relatively small amounts at the end of the exposure period, on the average 0.2 mg in all animals of the 30-mg groups. Only one male exposed to 30 mg/m3 showed a small amount of silica in the regional lymph node. During the post-exposure observation period, no silica could be recovered from any animal.

Applicant's summary and conclusion