Registration Dossier

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Reliability as taken from OECD SIDS "Synthetic amorphous silica and silicates", 2004.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
112945-52-5
EC Number:
601-216-3
Cas Number:
112945-52-5
IUPAC Name:
112945-52-5
Details on test material:
- Name of test material (as cited in study report): CAB-O-SIL M5
- Analytical purity: ca. 100%

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
whole body
Vehicle:
other: unchanged (no vehicle)
Analytical verification of test atmosphere concentrations:
yes
Duration of exposure:
4 h
Concentrations:
2.08 mg/L
No. of animals per sex per dose:
10
Control animals:
yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 2.08 mg/L air (analytical)
Exp. duration:
4 h

Any other information on results incl. tables

Particle size distribution was measured using a Delron Cascade impactor (MMAD = 0.76 µm ± 3.11). Approx. 84% of the particles had a diameter of =3 µm, approx. 98% =10 µm.No animals died. Nasal discharge during exposure, crusty eyes, crusty nose and alopecia at days post-exposure. No macroscopic organ lesions, but in one animal discoloration of the lung.

Applicant's summary and conclusion