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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: oral

Currently viewing:

Administrative data

Endpoint:
sub-chronic toxicity: oral
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Study period:
start 05.08.1974, duration 26 weeks
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: basic data given

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
Deviations:
yes
Remarks:
exposure time 26 weeks
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Reference substance name:
112926-00-8
EC Number:
601-214-2
Cas Number:
112926-00-8
IUPAC Name:
112926-00-8
Details on test material:
- Name of test material (as cited in study report): Syloid R 244
- Physical state: white powder
- Lot/batch No.: QD06-86-438 and QD10-86-665
- Stability under test conditions: stable
- Storage condition of test material: room temperature, protecetd from light

Test animals

Species:
rat
Strain:
CD-1
Sex:
male/female

Administration / exposure

Route of administration:
oral: feed
Vehicle:
unchanged (no vehicle)
Analytical verification of doses or concentrations:
no
Duration of treatment / exposure:
26 weeks
Frequency of treatment:
daily, seven days per week for 26 weeks
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 2.17-2.42, 7.95-8.98 g/kg bw and day
Basis:
nominal in diet
No. of animals per sex per dose:
12
Control animals:
yes, plain diet

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
> 8 980 mg/kg bw/day (nominal)
Sex:
male/female
Basis for effect level:
other: see 'Remark'
Remarks on result:
not determinable
Remarks:
no NOAEL identified

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

The concentrations used did not show any toxic effects in the parameters examined.

Applicant's summary and conclusion