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Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
sub-chronic toxicity: oral
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Study period:
start 05.08.1974, duration 26 weeks
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: basic data given

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report date:
1975

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
Deviations:
yes
Remarks:
exposure time 26 weeks
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Reference substance name:
112926-00-8
EC Number:
601-214-2
Cas Number:
112926-00-8
IUPAC Name:
112926-00-8
Details on test material:
- Name of test material (as cited in study report): Syloid R 244
- Physical state: white powder
- Lot/batch No.: QD06-86-438 and QD10-86-665
- Stability under test conditions: stable
- Storage condition of test material: room temperature, protecetd from light

Test animals

Species:
rat
Strain:
CD-1
Sex:
male/female

Administration / exposure

Route of administration:
oral: feed
Vehicle:
unchanged (no vehicle)
Analytical verification of doses or concentrations:
no
Duration of treatment / exposure:
26 weeks
Frequency of treatment:
daily, seven days per week for 26 weeks
Doses / concentrations
Remarks:
Doses / Concentrations:
0, 2.17-2.42, 7.95-8.98 g/kg bw and day
Basis:
nominal in diet
No. of animals per sex per dose:
12
Control animals:
yes, plain diet

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
> 8 980 mg/kg bw/day (nominal)
Sex:
male/female
Basis for effect level:
other: see 'Remark'
Remarks on result:
not determinable
Remarks:
no NOAEL identified

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

The concentrations used did not show any toxic effects in the parameters examined.

Applicant's summary and conclusion